null

SMILES C[C@H](NC(=O)[C@@H](O)c1cc(F)cc(F)c1)C(=O)N[C@H]1c2ccccc2-c2ccccc2N(C)C1=O

InChI Key InChIKey=ULSSJYNJIZWPSB-CVRXJBIPSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50241259   

TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)

Curated by ChEMBL
LigandPNGBDBM50241259((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)copy SMILEScopy InChI
Affinity DataIC50: 0.390nMAssay Description:Inhibition of gamma secretase mediated Notch signaling in HEK293 cells after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048X4PubMed
TargetPresenilin-1(Homo sapiens (Human))
Centre Hospitalier Universitaire Vaudois (CHUV)

Curated by ChEMBL
LigandPNGBDBM50241259((2S)-2-((S)-2-(3,5-difluorophenyl)-2-hydroxyacetam...)copy SMILEScopy InChI
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase in HEK293 cells expressing APP 695 assessed as reduction in amyloid beta levels after 5 hrs by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M048X4PubMed