null

SMILES [H][C@@]12COC[C@@]1(N=C(N)SC2)c1cc(NC(=O)c2ccc(F)cn2)ccc1F

InChI Key InChIKey=NIDRNVHMMDAAIK-YPMLDQLKSA-N

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50012647   

TargetBeta-secretase 1(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human BACE1 (1 to 460 residues) expressed in HEK293 cells using mcaFRET peptide as substrate after 20 hrs by FRET assayMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56P8KPubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Eli Lilly and Company

Curated by ChEMBL
LigandPNGBDBM50012647(CHEMBL2396989)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human BACE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56P8KPubMed