BindingDB

null

SMILES O=c1[nH]cnc2n[nH]cc12

InChI Key InChIKey=OFCNXPDARWKPPY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 35440

Xanthine dehydrogenase/oxidase(Bos taurus (Bovine))
Welfide Corporation

Curated by ChEMBL

BDBM35440(ALLOPURINOL | MLS000069453 | SMR000059083 | cid_20...)copy SMILEScopy InChI

IC50: 260nMAssay Description:In vitro inhibitory concentration against Xanthine oxidaseMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

Purchase PC cid PC sid Patents Similars

Details
BindingDB Entry DOI: 10.7270/Q2251HFCPubMed

Targets 4 ▿
- Xanthine dehydrogenase/oxidase 39
- Dual specificity protein phosphatase 1 1
- Purine nucleoside phosphorylase 1
- Dual specificity protein phosphatase 6 1
Publications 39 ▿
- J Med Chem 39: 2529-35 (1996) 2
- Bioorg Med Chem 19: 211-20 (2011) 2
- Bioorg Med Chem Lett 18: 5006-9 (2008) 2
- Bioorg Med Chem 19: 1950-8 (2011) 1
- Eur J Med Chem 46: 1222-31 (2011) 1
- Bioorg Chem 57: 57-64 (2014) 1
- Eur J Med Chem 75: 289-96 (2014) 1
- J Enzyme Inhib Med Chem 17: 45-8 (2002) 1
- Chem Biol Drug Des 82: 290-5 (2013) 1
- Bioorg Med Chem 19: 5569-76 (2011) 1
- Bioorg Med Chem 15: 3450-6 (2007) 1
- Bioorg Med Chem 18: 4769-74 (2011) 1
- Bioorg Med Chem Lett 22: 7543-6 (2012) 1
- PubChem Bioassay (2007) 1
- Bioorg Med Chem Lett 19: 6225-9 (2009) 1
- Bioorg Med Chem Lett 11: 879-82 (2001) 1
- Eur J Med Chem 43: 771-80 (2008) 1
- Bioorg Med Chem 17: 3414-25 (2009) 1
- Bioorg Med Chem 16: 7270-6 (2008) 1
- Bioorg Med Chem Lett 24: 495-500 (2014) 1
- Bioorg Med Chem 20: 5649-57 (2012) 1
- J Nat Prod 61: 71-6 (1998) 1
- Bioorg Med Chem Lett 23: 834-8 (2013) 1
- Chem Biol Drug Des 83: 119-25 (2014) 1
- Bioorg Med Chem Lett 13: 2777-80 (2003) 1
- Bioorg Med Chem 21: 365-72 (2012) 1
- J Med Chem 52: 7732-52 (2009) 1
- J Nat Prod 72: 1198-201 (2009) 1
- Bioorg Med Chem 20: 2930-9 (2012) 1
- J Nat Prod 52: 210-211 (1989) 1
- J Nat Prod 69: 1089-91 (2006) 1
- J Nat Prod 68: 1615-21 (2005) 1
- PubChem Bioassay (2007) 1
- J Nat Prod 71: 1027-31 (2008) 1
- J Nat Prod 73: 992-4 (2010) 1
- J Nat Prod 62: 1053-5 (1999) 1
- Eur J Med Chem 43: 862-71 (2008) 1
- Bioorg Med Chem Lett 17: 2558-60 (2007) 1
- J Nat Prod 68: 189-93 (2005) 1
Institutions 29 ▿
- [Piramal Healthcare Limited, Kaohsiung Medical University, Nanjing University] 3
- [Piramal Healthcare Limited, Kaohsiung Medical University, Nanjing University] 3
- [Piramal Healthcare Limited, Kaohsiung Medical University, Nanjing University] 3
- [Indo-Soviet Friendship College of Pharmacy, University of Pittsburgh Molecular Library Screening Center, Institute of Chemical Technology, AmorePacific Corporation, University of Mysore, Università di Modena, Pharmacy School of Wenzhou Medical College] 2
- [Indo-Soviet Friendship College of Pharmacy, University of Pittsburgh Molecular Library Screening Center, Institute of Chemical Technology, AmorePacific Corporation, University of Mysore, Università di Modena, Pharmacy School of Wenzhou Medical College] 2
- [Indo-Soviet Friendship College of Pharmacy, University of Pittsburgh Molecular Library Screening Center, Institute of Chemical Technology, AmorePacific Corporation, University of Mysore, Università di Modena, Pharmacy School of Wenzhou Medical College] 2
- [Indo-Soviet Friendship College of Pharmacy, University of Pittsburgh Molecular Library Screening Center, Institute of Chemical Technology, AmorePacific Corporation, University of Mysore, Università di Modena, Pharmacy School of Wenzhou Medical College] 2
- [Indo-Soviet Friendship College of Pharmacy, University of Pittsburgh Molecular Library Screening Center, Institute of Chemical Technology, AmorePacific Corporation, University of Mysore, Università di Modena, Pharmacy School of Wenzhou Medical College] 2
- [Indo-Soviet Friendship College of Pharmacy, University of Pittsburgh Molecular Library Screening Center, Institute of Chemical Technology, AmorePacific Corporation, University of Mysore, Università di Modena, Pharmacy School of Wenzhou Medical College] 2
- [Indo-Soviet Friendship College of Pharmacy, University of Pittsburgh Molecular Library Screening Center, Institute of Chemical Technology, AmorePacific Corporation, University of Mysore, Università di Modena, Pharmacy School of Wenzhou Medical College] 2
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
- [Hainan University, Chinese Academy of Sciences, Institute of Biological Chemistry and the Genomics Research Center, Solapur University, Konkuk University, SRTM University, Nanded, Maharashtra, 431606, India; Department of Molecular Biotechnology, College of Life and Environmental Sciences, Konkuk University, Seoul, 143-701, South Korea., Institute for Natural Product Research and Infection Biology, Central University of Punjab, Pontif£cia Universidade Cat£lica do Rio Grande do Sul (PUCRS), Guru Nanak Dev University, TBA, Welfide Corporation, University of Antwerp, Fuji Yakuhin Co., Ltd, University of Porto-Rua Anibal Cunha, Universidade do Minho, University of Karachi, Swami Ramanand Teerth Marathwada University, Chulabhorn Research Institute] 1
Affinity: 1.8E+2 to 1.0E+6 nM▿
- Ki 1
- IC50 40
- Kd 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1