null
SMILES Nc1nc(N)c(c(CCCc2ccccc2)n1)-c1cccc(Cl)c1
InChI Key InChIKey=CZDYZPVAAIFLQU-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 18786
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
Affinity DataKi: 1.20nMAssay Description:Inhibition of the wild-type dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
Affinity DataKi: 3nMAssay Description:Inhibition of the S108N mutant of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
Affinity DataKi: 4.20nMAssay Description:Inhibition of the C59R+S108N mutant of dihydrofolate reductase (DHFR)More data for this Ligand-Target Pair
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Plasmodium falciparum (isolate K1 / Thailand))
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
National Center for Genetic Engineering and Biotechnology
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Antiplasmodial activity (IC50) against Plasmodium falciparum Clone with mutant enzyme C59R+S108N- pfDihydrofolate reductase (K1CB1)More data for this Ligand-Target Pair