BindingDB

null

SMILES N[C@H]1C[C@@H]1c1ccccc1

InChI Key InChIKey=AELCINSCMGFISI-BDAKNGLRSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50236898

Trace amine-associated receptor 1(Homo sapiens (Human))
RTI International

Curated by ChEMBL

BDBM50236898((1S,2R)-(+)-2-phenylcyclopropylamine | CHEMBL25799...)copy SMILEScopy InChI

EC50: 1.51E+3nMAssay Description:Agonist activity at human trace amine associated receptor 1 expressed in RD-HGA16 CHO-K1 cells coexpressed with Galpha16 protein assessed as internal...More data for this Ligand-Target Pair

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Details Article
BindingDB Entry DOI: 10.7270/Q2DR2V92PubMed

Targets 10 ▿
- Lysine-specific histone demethylase 1A 17
- Amine oxidase [flavin-containing] A 9
- Amine oxidase [flavin-containing] B 8
- Alpha-1A adrenergic receptor 2
- REST corepressor 1 1
- Serine protease 1 1
- Cytochrome P450 2C19 1
- Trace amine-associated receptor 1 1
- Bile salt export pump 1
- Cytochrome P450 2B6 1
Publications 17 ▿
- Bioorg Med Chem 19: 3709-16 (2011) 4
- J Med Chem 54: 8236-50 (2011) 3
- Medchemcomm 5: 1863-1870 (2014) 3
- Eur J Med Chem 144: 52-67 (2018) 3
- J Med Chem 59: 253-63 (2016) 3
- J Med Chem 59: 1531-44 (2016) 3
- Chem Biol Drug Des 85: 659-71 (2015) 3
- Mol Pharmacol 13: 454-73 (1977) 2
- Bioorg Med Chem 16: 7148-66 (2008) 2
- J Med Chem 51: 2158-69 (2008) 2
- J Med Chem 52: 4551-73 (2009) 1
- Drug Metab Dispos 40: 2332-41 (2012) 1
- Bioorg Med Chem 26: 4871-4880 (2018) 1
- Bioorg Med Chem 16: 7415-23 (2008) 1
- Eur J Med Chem 125: 940-951 (2017) 1
- Bioorg Med Chem 19: 3702-8 (2011) 1
- J Med Chem 45: 2770-80 (2002) 1
Institutions 16 ▿
- [Kyoto Prefectural University of Medicine] 6
- [University of Southampton] 4
- [Medical University of South Carolina, China Pharmaceutical University, University of Freiburg, Baylor College of Medicine] 3
- [Medical University of South Carolina, China Pharmaceutical University, University of Freiburg, Baylor College of Medicine] 3
- [Medical University of South Carolina, China Pharmaceutical University, University of Freiburg, Baylor College of Medicine] 3
- [Medical University of South Carolina, China Pharmaceutical University, University of Freiburg, Baylor College of Medicine] 3
- [Universität Münster, TBA, Saarland University] 2
- [Universität Münster, TBA, Saarland University] 2
- [Universität Münster, TBA, Saarland University] 2
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
- [Johns Hopkins University, Fudan University, RTI International, AstraZeneca, Harvard University, Nagoya City University, Zhengzhou University] 1
Affinity: 8.5 to 1.3E+7 nM▿
- Ki 9
- IC50 31
- Kd 1
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1