BindingDB

null

SMILES CCOc1cc2ncc(C#N)c(Nc3ccc(F)c(Cl)c3)c2cc1NC(=O)\C=C\CN(C)C

InChI Key InChIKey=WVUNYSQLFKLYNI-AATRIKPKSA-N

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31090

Epidermal growth factor receptor(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL

BDBM31090((E)-N-[4-(3-chloro-4-fluoro-anilino)-3-cyano-7-eth...)copy SMILEScopy InChI

IC50: 80nMAssay Description:Concentration required to inhibit autophosphorylation of cytoplasmic domain of epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair

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Details Article
BindingDB Entry DOI: 10.7270/Q21Z4505PubMed

Targets 297 ▿
- Epidermal growth factor receptor 37
- Tyrosine-protein kinase ABL1 19
- Receptor tyrosine-protein kinase erbB-2 7
- Mast/stem cell growth factor receptor Kit 6
- Receptor-type tyrosine-protein kinase FLT3 5
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 4
- Cyclin-G-associated kinase 4
- Serine/threonine-protein kinase Nek2 4
- Serine/threonine-protein kinase 3 3
- Serine/threonine-protein kinase 17A 3
- Tyrosine-protein kinase Lck 3
- Tyrosine-protein kinase Fer 3
- Serine/threonine-protein kinase 4 3
- Serine/threonine-protein kinase 17B 3
- Tyrosine-protein kinase BTK 3
- Ephrin type-A receptor 6 3
- Death-associated protein kinase 3 3
- Dual specificity protein kinase CLK4 3
- Dual specificity protein kinase CLK3 3
- Dual specificity protein kinase CLK2 3
- BMP-2-inducible protein kinase 3
- Tyrosine-protein kinase FRK 3
- Calcium/calmodulin-dependent protein kinase kinase 2 3
- Serine/threonine-protein kinase 36 3
- Tyrosine-protein kinase SYK 3
- Ribosomal protein S6 kinase alpha-2 3
- Myosin light chain kinase 2, skeletal/cardiac muscle 3
- Calcium/calmodulin-dependent protein kinase type 1D 3
- STE20-like serine/threonine-protein kinase 3
- Mitogen-activated protein kinase kinase kinase kinase 5 3
- Vascular endothelial growth factor receptor 2 3
- Tyrosine-protein kinase HCK 3
- AP2-associated protein kinase 1 3
- Wee1-like protein kinase 3
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 3
- Tyrosine-protein kinase ABL2 3
- Mitogen-activated protein kinase kinase kinase 4 3
- Tyrosine-protein kinase Fyn 3
- Tyrosine-protein kinase CSK 3
- Tyrosine-protein kinase Lyn 3
- Serine/threonine-protein kinase PAK 1 3
- Ephrin type-B receptor 4 3
- TRAF2 and NCK-interacting protein kinase 3
- Activated CDC42 kinase 1 3
- Tyrosine-protein kinase Yes 3
- Ephrin type-A receptor 8 3
- Proto-oncogene tyrosine-protein kinase Src 3
- Casein kinase I isoform epsilon 3
- Tyrosine-protein kinase receptor Tie-1 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2
- Calcium/calmodulin-dependent protein kinase kinase 1 2
- Serine/threonine-protein kinase DCLK3 2
- Cyclin-dependent kinase 16 2
- Serine/threonine-protein kinase TNNI3K 2
- Interferon-induced, double-stranded RNA-activated protein kinase 2
- Angiopoietin-1 receptor 2
- Mitogen-activated protein kinase kinase kinase kinase 3 2
- Mitogen-activated protein kinase kinase kinase kinase 1 2
- Casein kinase I isoform alpha-like 2
- Mitogen-activated protein kinase kinase kinase kinase 4 2
- ALK tyrosine kinase receptor 2
- Hepatocyte growth factor receptor 2
- NUAK family SNF1-like kinase 2 2
- Mitogen-activated protein kinase 14 2
- Serine/threonine-protein kinase B-raf 2
- Cytoplasmic tyrosine-protein kinase BMX 2
- Serine/threonine-protein kinase Nek1 2
- Atypical kinase COQ8B, mitochondrial 2
- Dual specificity mitogen-activated protein kinase kinase 2 2
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 2
- Tyrosine-protein kinase JAK3 2
- Tyrosine-protein kinase JAK2 2
- Dual specificity mitogen-activated protein kinase kinase 1 2
- Serine/threonine-protein kinase 10 2
- Proto-oncogene tyrosine-protein kinase receptor Ret 2
- Serine/threonine-protein kinase SIK2 2
- Tyrosine-protein kinase Fes/Fps 2
- Myosin light chain kinase, smooth muscle 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 2
- Serine/threonine-protein kinase 38-like 2
- Ephrin type-A receptor 3 2
- Ephrin type-A receptor 5 2
- Dual specificity protein kinase CLK1 2
- Tyrosine-protein kinase ITK/TSK 2
- Myotonin-protein kinase 2
- Tyrosine-protein kinase receptor UFO 2
- Tyrosine-protein kinase Mer 2
- Tyrosine-protein kinase Blk 2
- Ribosomal protein S6 kinase alpha-1 2
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2
- Serine/threonine-protein kinase 32B 2
- Tyrosine-protein kinase Fgr 2
- Mitogen-activated protein kinase kinase kinase 20 2
- Fibroblast growth factor receptor 3 2
- Casein kinase I isoform delta 2
- Tyrosine-protein kinase receptor TYRO3 2
- Citron Rho-interacting kinase 2
- Macrophage colony-stimulating factor 1 receptor 2
- Ribosomal protein S6 kinase alpha-6 2
- eIF-2-alpha kinase GCN2 2
- Focal adhesion kinase 1 2
- Serine/threonine-protein kinase 24 2
- Ribosomal protein S6 kinase alpha-4 2
- Serine/threonine-protein kinase 25 2
- Ribosomal protein S6 kinase alpha-5 2
- Serine/threonine-protein kinase 33 2
- Serine/threonine-protein kinase MARK1 2
- Ephrin type-B receptor 1 2
- Serine/threonine-protein kinase Chk1 2
- Tyrosine-protein kinase TXK 2
- Tyrosine-protein kinase Tec 1
- Tubulin alpha-1A chain 1
- Tyrosine-protein kinase JAK1 1
- Receptor tyrosine-protein kinase erbB-4 1
- Cyclin-dependent kinase 11B 1
- Cyclin-dependent kinase 11A 1
- LIM domain kinase 1 1
- LIM domain kinase 2 1
- Non-receptor tyrosine-protein kinase TYK2 1
- Serine/threonine-protein kinase Nek9 1
- Serine/threonine-protein kinase Nek7 1
- Glycogen synthase kinase-3 alpha 1
- Glycogen synthase kinase-3 beta 1
- Calcium/calmodulin-dependent protein kinase type 1 1
- NUAK family SNF1-like kinase 1 1
- Serine/threonine-protein kinase Nek6 1
- Serine/threonine-protein kinase Nek5 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta 1
- Serine/threonine-protein kinase receptor R3 1
- MAP/microtubule affinity-regulating kinase 3 1
- Protein kinase C theta type 1
- MAP kinase-interacting serine/threonine-protein kinase 2 1
- Serine/threonine-protein kinase PAK 2 1
- MAP kinase-interacting serine/threonine-protein kinase 1 1
- Serine/threonine-protein kinase PAK 3 1
- Serine/threonine-protein kinase PAK 4 1
- Serine/threonine-protein kinase tousled-like 2 1
- Dual specificity mitogen-activated protein kinase kinase 3 1
- Serine/threonine-protein kinase PAK 5 1
- Serine/threonine-protein kinase PAK 6 1
- Serine/threonine-protein kinase tousled-like 1 1
- Epidermal growth factor receptor [1-999,L858R] 1
- MAP/microtubule affinity-regulating kinase 4 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Dual specificity mitogen-activated protein kinase kinase 4 1
- Tyrosine-protein kinase ZAP-70 1
- Casein kinase I isoform gamma-3 1
- Casein kinase I isoform gamma-2 1
- Casein kinase I isoform gamma-1 1
- Ephrin type-A receptor 1 1
- Dual specificity protein kinase TTK 1
- Myosin-IIIb 1
- Ephrin type-A receptor 2 1
- Myosin-IIIa 1
- Ephrin type-A receptor 4 1
- Insulin-like growth factor 1 receptor 1
- Protein kinase C eta type 1
- Activin receptor type-1 1
- Bone morphogenetic protein receptor type-1A 1
- Receptor-interacting serine/threonine-protein kinase 1 1
- Serine/threonine-protein kinase 16 1
- Receptor-interacting serine/threonine-protein kinase 2 1
- Non-receptor tyrosine-protein kinase TNK1 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Serine/threonine-protein kinase NLK 1
- Tyrosine-protein kinase Srms 1
- Cyclin-dependent kinase 18 [3-474] 1
- Ankyrin repeat and protein kinase domain-containing protein 1 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Serine/threonine-protein kinase 26 1
- Dual specificity testis-specific protein kinase 1 1
- Receptor-type tyrosine-protein kinase FLT3 [N841I] 1
- Cyclin-dependent kinase 2 1
- Ephrin type-B receptor 3 1
- Ephrin type-B receptor 2 1
- MAP kinase-activated protein kinase 2 1
- Platelet-derived growth factor receptor beta 1
- Epithelial discoidin domain-containing receptor 1 1
- MAP kinase-activated protein kinase 5 1
- Tyrosine-protein kinase ABL1 [1-999,Q252H] 1
- Muscle, skeletal receptor tyrosine-protein kinase 1
- Death-associated protein kinase 2 1
- Death-associated protein kinase 1 1
- Serine/threonine-protein kinase D2 1
- Serine/threonine-protein kinase D3 1
- Isoform 3 of Ribosomal protein S6 kinase alpha-2 (3) 1
- TGF-beta receptor type-2 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 1
- Serine/threonine-protein kinase D1 1
- Calcium/calmodulin-dependent protein kinase type II subunit delta 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Cyclin-dependent kinase 9 1
- Serine/threonine-protein kinase pim-3 1
- Cyclin-dependent kinase 8 1
- Cyclin-dependent kinase 7 1
- Serine/threonine-protein kinase pim-1 1
- Cyclin-dependent kinase 5 1
- Serine/threonine-protein kinase pim-2 1
- Serine/threonine-protein kinase DCLK1 1
- Serine/threonine-protein kinase DCLK2 1
- Cyclin-dependent kinase 3 1
- Testis-specific serine/threonine-protein kinase 1 1
- Protein kinase C epsilon type 1
- Cyclin-dependent kinase 17 1
- Bone morphogenetic protein receptor type-2 1
- Cyclin-dependent kinase 19 1
- Protein-tyrosine kinase 6 1
- Serine/threonine-protein kinase MRCK alpha 1
- Mitogen-activated protein kinase 15 1
- 5'-AMP-activated protein kinase catalytic subunit alpha-1 1
- Casein kinase II subunit alpha 1
- Activin receptor type-1B 1
- Cyclin-dependent kinase 14 1
- Leukocyte tyrosine kinase receptor 1
- Myosin light chain kinase family member 4 1
- Mitogen-activated protein kinase kinase kinase 9 1
- RAC-gamma serine/threonine-protein kinase 1
- Mitogen-activated protein kinase kinase kinase 5 1
- Interleukin-1 receptor-associated kinase 3 1
- Replicase polyprotein 1ab 1
- Tyrosine-protein kinase ABL1 [T315I] 1
- RAC-alpha serine/threonine-protein kinase 1
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 1
- cGMP-dependent protein kinase 2 1
- cGMP-dependent protein kinase 1 1
- Activin receptor type-2B 1
- Serine/threonine-protein kinase SIK1 1
- Activin receptor type-2A 1
- BDNF/NT-3 growth factors receptor 1
- Serine/threonine-protein kinase ULK3 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Mitogen-activated protein kinase 1 1
- Mitogen-activated protein kinase 3 1
- Discoidin domain-containing receptor 2 1
- Mitogen-activated protein kinase 4 1
- Ferrochelatase, mitochondrial [R115L] 1
- Protein kinase C delta type 1
- Mitogen-activated protein kinase 9 1
- NT-3 growth factor receptor 1
- SRSF protein kinase 2 1
- High affinity nerve growth factor receptor 1
- Protein-tyrosine kinase 2-beta 1
- Serine/threonine-protein kinase N2 1
- Mitogen-activated protein kinase 6 1
- cAMP-dependent protein kinase catalytic subunit beta 1
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 1
- Mitogen-activated protein kinase 7 1
- Receptor-type tyrosine-protein kinase FLT3 [D835H] 1
- Calcium/calmodulin-dependent protein kinase type IV 1
- Mitogen-activated protein kinase 8 1
- Serine/threonine-protein kinase N1 1
- Ribosomal protein S6 kinase alpha-3 1
- Serine/threonine-protein kinase RIO1 1
- Serine/threonine-protein kinase LATS1 1
- Calcium/calmodulin-dependent protein kinase type 1G 1
- Serine/threonine-protein kinase RIO3 1
- Fibroblast growth factor receptor 4 1
- Serine/threonine-protein kinase 32C 1
- Insulin receptor 1
- Aurora kinase B 1
- Receptor-type tyrosine-protein kinase FLT3 [D835Y] 1
- Vascular endothelial growth factor receptor 3 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 1 1
- Fibroblast growth factor receptor 2 1
- Atypical kinase COQ8A, mitochondrial 1
- Vascular endothelial growth factor receptor 1 1
- Aurora kinase C 1
- Serine/threonine-protein kinase PLK1 1
- Insulin receptor-related protein 1
- Serine/threonine-protein kinase PLK3 1
- Serine/threonine-protein kinase PLK4 1
- Mitogen-activated protein kinase 12 1
- Wee1-like protein kinase 2 1
- Mitogen-activated protein kinase 11 1
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 1
- RAC-beta serine/threonine-protein kinase 1
- Mitogen-activated protein kinase 10 1
- Serine/threonine-protein kinase BRSK1 1
- Serine/threonine-protein kinase LATS2 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Platelet-derived growth factor receptor alpha 1
- Serine/threonine-protein kinase BRSK2 1
- Maternal embryonic leucine zipper kinase 1
- Serine/threonine-protein kinase MARK2 1
- Dual specificity protein kinase CLK1 [R432A] 1
- Epidermal growth factor receptor [G719C] 1
- cAMP-dependent protein kinase catalytic subunit PRKX 1
- SRSF protein kinase 1 1
- Mitogen-activated protein kinase kinase kinase 12 1
- Serine/threonine-protein kinase MRCK beta 1
- Serine/threonine-protein kinase MRCK gamma 1
- Mitogen-activated protein kinase kinase kinase 10 1
- Mitogen-activated protein kinase kinase kinase 11 1
- Ephrin type-A receptor 3 [1-975] 1
- Casein kinase II subunit alpha' 1
- Serine/threonine-protein kinase STK11 1
- ...
Publications 50 ▿
- Nat Biotechnol 26: 127-32 (2008) 317
- Nat Biotechnol 23: 329-36 (2005) 62
- PubChem Bioassay (2008) 13
- Bioorg Med Chem 15: 3635-48 (2007) 4
- J Med Chem 60: 7863-7875 (2017) 3
- J Med Chem 46: 49-63 (2002) 2
- J Med Chem 48: 1107-31 (2005) 2
- Bioorg Med Chem Lett 14: 1411-6 (2004) 2
- J Med Chem 57: 5835-44 (2014) 2
- Bioorg Med Chem Lett 12: 2893-7 (2002) 2
- J Med Chem 63: 441-469 (2020) 2
- Bioorg Med Chem 18: 6634-45 (2010) 2
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- Eur J Med Chem 102: 115-31 (2015) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- bioRxiv 2020: (2020) 1
- PubChem Bioassay (2008) 1
- Bioorg Med Chem Lett 14: 3397-400 (2004) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- J Med Chem 58: 3393-410 (2015) 1
- J Med Chem 62: 4772-4778 (2019) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- ...
Institutions 11 ▿
- [Ambit Biosciences] 425
- [Wyeth Research] 12
- [Moffitt Cancer Center] 3
- [Imperial College London, The University of Arizona, University of Arkansas for Medical Sciences] 2
- [Imperial College London, The University of Arizona, University of Arkansas for Medical Sciences] 2
- [Imperial College London, The University of Arizona, University of Arkansas for Medical Sciences] 2
- [Jazan University, Center for Free-Electron Laser Science, KU Leuven, Georgetown University, University of North Carolina at Chapel Hill] 1
- [Jazan University, Center for Free-Electron Laser Science, KU Leuven, Georgetown University, University of North Carolina at Chapel Hill] 1
- [Jazan University, Center for Free-Electron Laser Science, KU Leuven, Georgetown University, University of North Carolina at Chapel Hill] 1
- [Jazan University, Center for Free-Electron Laser Science, KU Leuven, Georgetown University, University of North Carolina at Chapel Hill] 1
- [Jazan University, Center for Free-Electron Laser Science, KU Leuven, Georgetown University, University of North Carolina at Chapel Hill] 1
- ...
Affinity: 0.23 to 8.7E+6 nM▿
- Ki 3
- IC50 25
- Kd 488
- EC50 1
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1