BindingDB

null

SMILES CN1C2CCCC1CC(C2)NC(=O)c1nn(C)c2ccccc12

InChI Key InChIKey=MFWNKCLOYSRHCJ-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50000483

5-hydroxytryptamine receptor 3A/3B(Rattus norvegicus)
Rh£ne-Poulenc Rorer Central Research

Curated by ChEMBL

BDBM50000483((BRL 43694)1-Methyl-1H-indazole-3-carboxylic acid ...)copy SMILEScopy InChI

Ki: 1.70nMAssay Description:Displacement of the 5-hydroxytryptamine 3 receptor ligand [3H]GR-65630 from rat brain cortical membranes.More data for this Ligand-Target Pair

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Details
BindingDB Entry DOI: 10.7270/Q2SJ1M77PubMed PDB

3D Structure (crystal)

Targets 17 ▿
- 5-hydroxytryptamine receptor 3A/3B 15
- 5-hydroxytryptamine receptor 3A 4
- Potassium voltage-gated channel subfamily H member 2 4
- 5-hydroxytryptamine receptor 7 2
- Solute carrier family 22 member 2 1
- Multidrug and toxin extrusion protein 1 1
- Neuronal acetylcholine receptor subunit alpha-3 1
- Serotonin 2 (5-HT2) receptor 1
- Neuronal acetylcholine receptor subunit alpha-7 1
- Neuronal acetylcholine receptor subunit alpha-4/beta-2 1
- 5-hydroxytryptamine receptor 2C 1
- 5-hydroxytryptamine receptor 1B 1
- D(2) dopamine receptor 1
- Multidrug and toxin extrusion protein 2 1
- 5-hydroxytryptamine receptor 1A 1
- 5-hydroxytryptamine receptor 4 1
- 5-hydroxytryptamine receptor 1D 1
Publications 19 ▿
- J Med Chem 33: 3176-81 (1991) 7
- J Med Chem 33: 1924-9 (1990) 3
- Bioorg Med Chem Lett 11: 319-21 (2001) 3
- J Med Chem 56: 781-95 (2013) 3
- J Med Chem 33: 1594-600 (1990) 3
- Bioorg Med Chem Lett 12: 189-92 (2001) 3
- J Biol Chem 268: 18200-4 (1993) 2
- Bioorg Med Chem Lett 2: 461-466 (1992) 1
- Eur J Med Chem 45: 4746-60 (2010) 1
- J Med Chem 35: 895-903 (1992) 1
- Bioorg Med Chem Lett 22: 1151-5 (2012) 1
- Eur J Med Chem 46: 618-30 (2011) 1
- Bioorg Med Chem Lett 15: 2886-90 (2005) 1
- J Med Chem 53: 2324-8 (2010) 1
- J Med Chem 35: 4893-902 (1992) 1
- J Med Chem 45: 3844-53 (2002) 1
- J Med Chem 36: 3693-9 (1994) 1
- Eur J Med Chem 44: 1926-32 (2009) 1
- J Med Chem 40: 586-93 (1997) 1
Institutions 19 ▿
- [Lilly Research Laboratories] 7
- [Merrell Dow Research Institute, Beecham Pharmaceuticals Research Division, University of California, AstraZeneca, Universidad de Alcal£] 3
- [Merrell Dow Research Institute, Beecham Pharmaceuticals Research Division, University of California, AstraZeneca, Universidad de Alcal£] 3
- [Merrell Dow Research Institute, Beecham Pharmaceuticals Research Division, University of California, AstraZeneca, Universidad de Alcal£] 3
- [Merrell Dow Research Institute, Beecham Pharmaceuticals Research Division, University of California, AstraZeneca, Universidad de Alcal£] 3
- [Merrell Dow Research Institute, Beecham Pharmaceuticals Research Division, University of California, AstraZeneca, Universidad de Alcal£] 3
- [National Institute of Neurological Disorders and Stroke] 2
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
- [TBA, University of Bern, Solvay Duphar B.V., Kyowa Hakko Kogyo Co., Rh£ne-Poulenc Rorer Central Research, CASMedChem Laboratory, Reverse proteomics research institute, University of Modena and Reggio Emilia, TCG Lifesciences Ltd., University of Bologna, University of Warwick, FAES, S.A.] 1
Affinity: 0.25 to 3.1E+5 nM▿
- Ki 26
- IC50 10
- Kd 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1