BindingDB

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SMILES CN(C)CCCSc1ccccc1NC(=O)\C=C\c1ccccc1

InChI Key InChIKey=RSUVYMGADVXGOU-BUHFOSPRSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50016900

5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Universit£ degli Studi di Sassari

Curated by ChEMBL

BDBM50016900((E)-N-[2-(3-Dimethylamino-propylsulfanyl)-phenyl]-...)copy SMILEScopy InChI

IC50: 14.8nMAssay Description:In vitro binding affinity for serotonin 5-hydroxytryptamine 2A receptor of rat cerebral cortex using [3H]ketanserin as radioligandMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Details
BindingDB Entry DOI: 10.7270/Q21G0N0MPubMed

Targets 12 ▿
- 5-hydroxytryptamine receptor 2A 12
- Replicase polyprotein 1ab 4
- Serotonin 2 (5-HT2) receptor 4
- Platelet glycoprotein VI 4
- 5-hydroxytryptamine receptor 1A 2
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 1
- Sigma non-opioid intracellular receptor 1 1
- 5-hydroxytryptamine receptor 1B 1
- 5-hydroxytryptamine receptor 2C 1
- 5-hydroxytryptamine receptor 2B 1
- D(2) dopamine receptor 1
- D(1A) dopamine receptor 1
Publications 13 ▿
- J Med Chem 30: 1-12 (1987) 6
- Bioorg Med Chem 16: 6116-23 (2008) 4
- Life Sci 33: 2011-6 (1983) 3
- Nature 305: 140-2 (1983) 2
- Neuropharmacology 33: 275-317 (1994) 2
- J Neurosci 9: 3482-90 (1989) 2
- J Med Chem 60: 322-337 (2017) 2
- J Med Chem 32: 720-7 (1989) 1
- J Med Chem 37: 4109-17 (1995) 1
- J Med Chem 45: 4655-68 (2002) 1
- J Pharmacol Exp Ther 283: 1305-22 (1997) 1
- J Pharmacol Exp Ther 262: 929-35 (1992) 1
- J Pharmacol Exp Ther 253: 214-20 (1990) 1
Institutions 13 ▿
- [TBA] 6
- [Purdue University] 4
- [University of Toronto] 3
- [Academy of Scientific and Innovative Research, Stanford University, University of Alberta, INSERM U. 114] 2
- [Academy of Scientific and Innovative Research, Stanford University, University of Alberta, INSERM U. 114] 2
- [Academy of Scientific and Innovative Research, Stanford University, University of Alberta, INSERM U. 114] 2
- [Academy of Scientific and Innovative Research, Stanford University, University of Alberta, INSERM U. 114] 2
- [University of North Carolina, DuPont Merck Pharmaceutical Company, CIBA-GEIGY Corporation, Emory University, University of Nebraska , Universit£ degli Studi di Sassari] 1
- [University of North Carolina, DuPont Merck Pharmaceutical Company, CIBA-GEIGY Corporation, Emory University, University of Nebraska , Universit£ degli Studi di Sassari] 1
- [University of North Carolina, DuPont Merck Pharmaceutical Company, CIBA-GEIGY Corporation, Emory University, University of Nebraska , Universit£ degli Studi di Sassari] 1
- [University of North Carolina, DuPont Merck Pharmaceutical Company, CIBA-GEIGY Corporation, Emory University, University of Nebraska , Universit£ degli Studi di Sassari] 1
- [University of North Carolina, DuPont Merck Pharmaceutical Company, CIBA-GEIGY Corporation, Emory University, University of Nebraska , Universit£ degli Studi di Sassari] 1
- [University of North Carolina, DuPont Merck Pharmaceutical Company, CIBA-GEIGY Corporation, Emory University, University of Nebraska , Universit£ degli Studi di Sassari] 1
Affinity: 2 to 1.3E+5 nM▿
- Ki 22
- IC50 11
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1