BindingDB

null

SMILES C[C@H](CCC(=O)NCCS(O)(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@@H]4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C

InChI Key InChIKey=WBWWGRHZICKQGZ-HZAMXZRMSA-N

PDB links: 15 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50375594

G-protein coupled bile acid receptor 1(Homo sapiens (Human))
INSERM

Curated by ChEMBL

BDBM50375594(TAUROCHOLATE)copy SMILEScopy InChI

EC50: 4.95E+3nMAssay Description:Agonist activity at human TGR5 expressed in CHO cells by luciferase assayMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
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Details Article
BindingDB Entry DOI: 10.7270/Q2222VNJPubMed

Targets 12 ▿
- Solute carrier organic anion transporter family member 1A4 3
- ATP-binding cassette sub-family C member 4 2
- Sodium/bile acid cotransporter 2
- Solute carrier organic anion transporter family member 1A1 2
- Solute carrier organic anion transporter family member 1C1 1
- G-protein coupled bile acid receptor 1 1
- Solute carrier family 22 member 6 1
- Solute carrier organic anion transporter family member 1
- Solute carrier family 22 member 8 1
- Ileal sodium/bile acid cotransporter 1
- ABC-type glutathione-S-conjugate transporter 1
- Solute carrier organic anion transporter family member 1A3 1
Publications 14 ▿
- J Pharmacol Exp Ther 298: 316-22 (2001) 4
- J Biol Chem 288: 33894-911 (2013) 1
- J Med Chem 51: 1831-41 (2008) 1
- Am J Physiol 274: 157-69 (1998) 1
- J Pharmacol Exp Ther 293: 1034-9 (2000) 1
- J Pharmacol Exp Ther 291: 1204-9 (1999) 1
- Bioorg Med Chem Lett 14: 4179-83 (2004) 1
- J Pharmacol Exp Ther 299: 261-7 (2001) 1
- Int J Biochem Cell Biol 36: 247-57 (2004) 1
- Hepatology 28: 1341-6 (1998) 1
- Biochem J 371: 361-7 (2003) 1
- Endocrinology 145: 4384-91 (2004) 1
- Biochemistry 42: 9989-10000 (2003) 1
- Drug Metab Dispos 30: 220-3 (2002) 1
Institutions 12 ▿
- [The University of Tokyo] 5
- [Kyoto University Hospital] 2
- [INSERM, Wake Forest University, Abbott Laboratories, National University of Singapore, Queen's University, Rudjer Boskovic Institute, Vanderbilt University School of Medicine, The Netherlands Cancer Institute, the University of Tokyo, University of Toronto] 1
- [INSERM, Wake Forest University, Abbott Laboratories, National University of Singapore, Queen's University, Rudjer Boskovic Institute, Vanderbilt University School of Medicine, The Netherlands Cancer Institute, the University of Tokyo, University of Toronto] 1
- [INSERM, Wake Forest University, Abbott Laboratories, National University of Singapore, Queen's University, Rudjer Boskovic Institute, Vanderbilt University School of Medicine, The Netherlands Cancer Institute, the University of Tokyo, University of Toronto] 1
- [INSERM, Wake Forest University, Abbott Laboratories, National University of Singapore, Queen's University, Rudjer Boskovic Institute, Vanderbilt University School of Medicine, The Netherlands Cancer Institute, the University of Tokyo, University of Toronto] 1
- [INSERM, Wake Forest University, Abbott Laboratories, National University of Singapore, Queen's University, Rudjer Boskovic Institute, Vanderbilt University School of Medicine, The Netherlands Cancer Institute, the University of Tokyo, University of Toronto] 1
- [INSERM, Wake Forest University, Abbott Laboratories, National University of Singapore, Queen's University, Rudjer Boskovic Institute, Vanderbilt University School of Medicine, The Netherlands Cancer Institute, the University of Tokyo, University of Toronto] 1
- [INSERM, Wake Forest University, Abbott Laboratories, National University of Singapore, Queen's University, Rudjer Boskovic Institute, Vanderbilt University School of Medicine, The Netherlands Cancer Institute, the University of Tokyo, University of Toronto] 1
- [INSERM, Wake Forest University, Abbott Laboratories, National University of Singapore, Queen's University, Rudjer Boskovic Institute, Vanderbilt University School of Medicine, The Netherlands Cancer Institute, the University of Tokyo, University of Toronto] 1
- [INSERM, Wake Forest University, Abbott Laboratories, National University of Singapore, Queen's University, Rudjer Boskovic Institute, Vanderbilt University School of Medicine, The Netherlands Cancer Institute, the University of Tokyo, University of Toronto] 1
- [INSERM, Wake Forest University, Abbott Laboratories, National University of Singapore, Queen's University, Rudjer Boskovic Institute, Vanderbilt University School of Medicine, The Netherlands Cancer Institute, the University of Tokyo, University of Toronto] 1
Affinity: 5.0E+3 to 2.8E+6 nM▿
- Ki 10
- IC50 6
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1