BindingDB

null

SMILES NC(=S)C(=C\c1ccc(O)c(O)c1)\C#N

InChI Key InChIKey=ZGHQGWOETPXKLY-XVNBXDOJSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4363

Insulin receptor(Homo sapiens (Human))
Institute of Molecular Physiology

Curated by ChEMBL

BDBM4363((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)copy SMILEScopy InChI

IC50: 6.40E+5nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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Details Article
BindingDB Entry DOI: 10.7270/Q2M046C4PubMed

Epidermal growth factor receptor(Homo sapiens (Human))
Institute of Molecular Physiology

Curated by ChEMBL

BDBM4363((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enethio...)copy SMILEScopy InChI

IC50: 2.40E+3nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL MCE
PC cid PC sid Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2M046C4PubMed

Targets 9 ▿
- Epidermal growth factor receptor 5
- Macrophage colony-stimulating factor 1 receptor [538-678,753-922] 2
- Tyrosine-protein kinase SYK 1
- Protein-glutamine gamma-glutamyltransferase 2/Receptor protein-tyrosine kinase 1
- Tyrosyl-DNA phosphodiesterase 1 1
- Insulin receptor 1
- Receptor tyrosine-protein kinase erbB-2 1
- Dynamin-1 1
- Macrophage colony-stimulating factor 1 receptor [538-972] 1
Publications 10 ▿
- J Biol Chem 282: 4085-93 (2007) 3
- Bioorg Med Chem 17: 1079-87 (2009) 2
- Eur J Med Chem 43: 1478-88 (2008) 2
- J Med Chem 48: 7781-8 (2005) 1
- J Med Chem 44: 281-97 (2001) 1
- Bioorg Med Chem Lett 19: 1944-9 (2009) 1
- J Nat Prod 55: 1529-1560 (1992) 1
- Chem Biol 15: 969-78 (2008) 1
- J Med Chem 32: 2344-52 (1989) 1
- J Med Chem 55: 8671-84 (2012) 1
Institutions 10 ▿
- [Johnson & Johnson Pharmaceutical] 3
- [Freie Universität Berlin, Institute of Molecular Physiology] 2
- [Freie Universität Berlin, Institute of Molecular Physiology] 2
- [Hebrew University of Jerusalem, TBA, Duke University Medical Center, The University of Newcastle, University of Minnesota, Sichuan University, Allergan Inc.] 1
- [Hebrew University of Jerusalem, TBA, Duke University Medical Center, The University of Newcastle, University of Minnesota, Sichuan University, Allergan Inc.] 1
- [Hebrew University of Jerusalem, TBA, Duke University Medical Center, The University of Newcastle, University of Minnesota, Sichuan University, Allergan Inc.] 1
- [Hebrew University of Jerusalem, TBA, Duke University Medical Center, The University of Newcastle, University of Minnesota, Sichuan University, Allergan Inc.] 1
- [Hebrew University of Jerusalem, TBA, Duke University Medical Center, The University of Newcastle, University of Minnesota, Sichuan University, Allergan Inc.] 1
- [Hebrew University of Jerusalem, TBA, Duke University Medical Center, The University of Newcastle, University of Minnesota, Sichuan University, Allergan Inc.] 1
- [Hebrew University of Jerusalem, TBA, Duke University Medical Center, The University of Newcastle, University of Minnesota, Sichuan University, Allergan Inc.] 1
Affinity: 8.5E+2 to 6.4E+5 nM▿
- Ki 1
- IC50 14
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1