BindingDB

null

SMILES CN[C@@H]1CC2O[C@@](C)([C@@H]1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13

InChI Key InChIKey=HKSZLNNOFSGOKW-ZGQXJOJZSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50059889

Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals Inc

Curated by ChEMBL

BDBM50059889((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...)copy SMILEScopy InChI

Ki: 22nMAssay Description:Inhibition of GSK3-beta assessed as NADH level after 10 mins by pyruvate kinase/lactate dehydrogenase coupled spectrophotometric assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
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Details Article
BindingDB Entry DOI: 10.7270/Q2TX3G9BPubMed

Targets 48 ▿
- Glycogen synthase kinase-3 beta 8
- MAP kinase-activated protein kinase 2 7
- Tyrosine-protein kinase Fyn 7
- Vascular endothelial growth factor receptor 2 7
- Insulin-like growth factor 1 receptor 5
- Proto-oncogene tyrosine-protein kinase Src 4
- Telomerase reverse transcriptase 3
- Mitogen-activated protein kinase kinase kinase 5 3
- Tyrosine-protein kinase SYK 2
- Receptor-type tyrosine-protein kinase FLT3 2
- Tyrosine-protein kinase Lck 2
- Protein kinase C epsilon type 2
- Mitogen-activated protein kinase 3 2
- Inhibitor of nuclear factor kappa-B kinase subunit beta 2
- Tyrosine-protein kinase JAK3 2
- Dual specificity mitogen-activated protein kinase kinase 1 2
- TRAF2 and NCK-interacting protein kinase 2
- Tyrosine-protein kinase ZAP-70 2
- MO15-related protein kinase Pfmrk 2
- Cyclin-dependent kinase 5 activator 1 2
- Mitogen-activated protein kinase 1 1
- TGF-beta receptor type-1 1
- Mitogen-activated protein kinase kinase kinase 14 1
- Protein kinase C delta type 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Serine/threonine-protein kinase pim-1 1
- Serine/threonine-protein kinase pim-2 1
- Epidermal growth factor receptor 1
- Mitogen-activated protein kinase 8 1
- Lysine--tRNA ligase 1
- Mast/stem cell growth factor receptor Kit 1
- Cyclin-A2/Cyclin-dependent kinase 1 1
- Cyclin-H/Cyclin-dependent kinase 7 1
- Cyclin-K/Cyclin-dependent kinase 9 1
- Casein kinase II subunit alpha 1
- Aurora kinase A 1
- Protein kinase C iota type 1
- Cyclin-dependent kinase 3/G1/S-specific cyclin-E1 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Tyrosine-protein kinase receptor TYRO3 1
- Protein kinase C beta type 1
- Casein kinase I isoform alpha 1
- Protein kinase C gamma type 1
- Tyrosine-protein kinase Lyn 1
- Serine/threonine-protein kinase Chk2 1
- Leucine-rich repeat serine/threonine-protein kinase 2 1
- Mitogen-activated protein kinase kinase kinase 11 1
- Cyclin-dependent kinase 6/G1/S-specific cyclin-D1 1
- ...
Publications 45 ▿
- Eur J Med Chem 45: 3389-93 (2010) 9
- Bioorg Med Chem 17: 4302-12 (2009) 7
- J Med Chem 56: 3768-82 (2013) 6
- J Med Chem 50: 1090-100 (2007) 6
- Bioorg Med Chem 19: 5342-51 (2011) 5
- J Biol Chem 282: 33052-63 (2007) 4
- Bioorg Med Chem Lett 21: 2224-8 (2011) 4
- Bioorg Med Chem Lett 20: 330-3 (2010) 4
- Bioorg Med Chem 16: 7347-57 (2008) 4
- Bioorg Med Chem Lett 19: 6557-60 (2009) 3
- Eur J Med Chem 46: 1245-53 (2011) 3
- Bioorg Med Chem Lett 18: 3752-5 (2008) 3
- Bioorg Med Chem Lett 23: 569-73 (2012) 2
- J Med Chem 45: 529-32 (2002) 2
- Bioorg Med Chem Lett 22: 591-6 (2011) 2
- Bioorg Med Chem 16: 9247-60 (2008) 2
- J Med Chem 56: 8032-48 (2013) 2
- J Med Chem 47: 5418-26 (2004) 1
- Bioorg Med Chem Lett 23: 1083-6 (2013) 1
- Bioorg Med Chem Lett 23: 5150-4 (2013) 1
- Bioorg Med Chem Lett 21: 449-52 (2010) 1
- J Med Chem 55: 6700-15 (2012) 1
- Bioorg Med Chem Lett 17: 326-31 (2007) 1
- Bioorg Med Chem Lett 19: 4720-3 (2009) 1
- Eur J Med Chem 44: 2361-71 (2009) 1
- J Med Chem 47: 3934-7 (2004) 1
- Bioorg Med Chem 20: 6821-30 (2012) 1
- Bioorg Med Chem 20: 6356-65 (2012) 1
- Bioorg Med Chem Lett 19: 3333-8 (2009) 1
- J Nat Prod 72: 1699-701 (2009) 1
- Bioorg Med Chem Lett 19: 1944-9 (2009) 1
- Eur J Med Chem 60: 23-8 (2013) 1
- Bioorg Med Chem Lett 21: 1342-6 (2011) 1
- Bioorg Med Chem 19: 6518-24 (2011) 1
- Bioorg Med Chem Lett 20: 1661-4 (2010) 1
- Bioorg Med Chem Lett 22: 410-4 (2011) 1
- J Med Chem 46: 3333-41 (2003) 1
- Bioorg Med Chem Lett 23: 3690-6 (2013) 1
- J Med Chem 53: 2433-42 (2010) 1
- Eur J Med Chem 46: 2043-57 (2011) 1
- J Med Chem 46: 3877-82 (2003) 1
- J Med Chem 55: 6832-48 (2012) 1
- Bioorg Med Chem Lett 20: 4515-20 (2010) 1
- Bioorg Med Chem Lett 19: 1512-6 (2009) 1
- J Nat Prod 71: 451-2 (2008) 1
Institutions 40 ▿
- [Centre Universitaire] 9
- [Zhejiang University] 7
- [Kissei Pharmaceutical Company Ltd, GlaxoSmithKline Research Centre Zagreb, H. Lee Moffitt Cancer Center and Research Institute] 6
- [Kissei Pharmaceutical Company Ltd, GlaxoSmithKline Research Centre Zagreb, H. Lee Moffitt Cancer Center and Research Institute] 6
- [Kissei Pharmaceutical Company Ltd, GlaxoSmithKline Research Centre Zagreb, H. Lee Moffitt Cancer Center and Research Institute] 6
- [Takeda Pharmaceutical Company Ltd] 5
- [Abbott Laboratories, Sanofi-aventis, University of California-San Francisco] 4
- [Abbott Laboratories, Sanofi-aventis, University of California-San Francisco] 4
- [Abbott Laboratories, Sanofi-aventis, University of California-San Francisco] 4
- [Osaka Prefecture University, Universidade Federal do Rio de Janeiro, The University of Tokyo] 3
- [Osaka Prefecture University, Universidade Federal do Rio de Janeiro, The University of Tokyo] 3
- [Osaka Prefecture University, Universidade Federal do Rio de Janeiro, The University of Tokyo] 3
- [Institute of Technology and Science, Astex Pharmaceuticals, Inc., Califia Bio Inc., Kyung Hee University, Carna Biosciences, Inc., University of Utah, Nanjing University, Griffith University] 2
- [Institute of Technology and Science, Astex Pharmaceuticals, Inc., Califia Bio Inc., Kyung Hee University, Carna Biosciences, Inc., University of Utah, Nanjing University, Griffith University] 2
- [Institute of Technology and Science, Astex Pharmaceuticals, Inc., Califia Bio Inc., Kyung Hee University, Carna Biosciences, Inc., University of Utah, Nanjing University, Griffith University] 2
- [Institute of Technology and Science, Astex Pharmaceuticals, Inc., Califia Bio Inc., Kyung Hee University, Carna Biosciences, Inc., University of Utah, Nanjing University, Griffith University] 2
- [Institute of Technology and Science, Astex Pharmaceuticals, Inc., Califia Bio Inc., Kyung Hee University, Carna Biosciences, Inc., University of Utah, Nanjing University, Griffith University] 2
- [Institute of Technology and Science, Astex Pharmaceuticals, Inc., Califia Bio Inc., Kyung Hee University, Carna Biosciences, Inc., University of Utah, Nanjing University, Griffith University] 2
- [Institute of Technology and Science, Astex Pharmaceuticals, Inc., Califia Bio Inc., Kyung Hee University, Carna Biosciences, Inc., University of Utah, Nanjing University, Griffith University] 2
- [Institute of Technology and Science, Astex Pharmaceuticals, Inc., Califia Bio Inc., Kyung Hee University, Carna Biosciences, Inc., University of Utah, Nanjing University, Griffith University] 2
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
- [Sterling Road, The University of Sydney, Ewha Womans University, Lilly Research Laboratories, Technische Universitat Braunschweig, Vertex Pharmaceuticals Inc, Novo Nordisk A/S, Johnson& Johnson Pharmaceutical Research& Development L.L.C. 920 Route 202, Sichuan University, Teijin Pharma Ltd., Georgetown University Medical Center , Johnson & Johnson Pharmaceutical Research and Development, University of Namur, Institute of Research, Universit£ degli Studi di Siena, University of Delhi, Birla Institute of Technology and Science, Walter Reed Army Institute of Research, University of the Pacific, Shandong University of Technology] 1
Affinity: 0.070 to 8.3E+3 nM▿
- Ki 2
- IC50 90
- Kd 4
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 2
Catalog Cmpds: 1