BindingDB

null

SMILES Oc1cccc2cccnc12

InChI Key InChIKey=MCJGNVYPOGVAJF-UHFFFAOYSA-N

PDB links: 3 PDB IDs match this monomer. 6 PDB IDs contain this monomer as substructures. 6 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 32203

Methionine aminopeptidase 1(Homo sapiens (Human))
Universit£t Heidelberg

Curated by ChEMBL

BDBM32203(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)copy SMILEScopy InChI

IC50: 2.15E+4nMAssay Description:Inhibition of human MetAP1More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2RF5W0KPubMed

Methionine aminopeptidase 2(Homo sapiens (Human))
Universit£t Heidelberg

Curated by ChEMBL

BDBM32203(8-quinolinol | CHEMBL310555 | US10005735, Table 1....)copy SMILEScopy InChI

IC50: 5.60E+3nMAssay Description:Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cellsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Purchase CHEMBL MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2RF5W0KPubMed

Targets 17 ▿
- Methionine aminopeptidase 2 3
- Methionine aminopeptidase 1 3
- Botulinum neurotoxin type A 2
- 26S proteasome non-ATPase regulatory subunit 14 2
- Thermolysin 2
- Lanosterol synthase 2
- Platelet-activating factor acetylhydrolase 2
- Histone deacetylase 8 1
- Indoleamine 2,3-dioxygenase 1 1
- Glutaminyl-peptide cyclotransferase 1
- Fructose-bisphosphate aldolase 1
- Cholesterol side-chain cleavage enzyme, mitochondrial 1
- Heat shock protein HSP 90-alpha 1
- 72 kDa type IV collagenase 1
- Acetylcholinesterase 1
- Cholinesterase 1
- Bile salt export pump 1
Publications 16 ▿
- Bioorg Med Chem Lett 20: 4038-44 (2010) 2
- Bioorg Med Chem Lett 22: 868-71 (2012) 2
- J Med Chem 53: 4927-37 (2010) 2
- J Med Chem 52: 48-61 (2009) 2
- J Med Chem 61: 9647-9665 (2018) 2
- Bioorg Med Chem 25: 813-824 (2017) 2
- ACS Med Chem Lett 4: (2013) 2
- Drug Metab Dispos 40: 2332-41 (2012) 1
- J Med Chem 57: 669-76 (2014) 1
- J Med Chem 54: 591-602 (2011) 1
- Bioorg Med Chem Lett 27: 675-678 (2017) 1
- PubChem Bioassay (2007) 1
- US Patent US9394254 (2016) 1
- J Med Chem 60: 1343-1361 (2017) 1
- Bioorg Med Chem 17: 8086-92 (2009) 1
- J Med Chem 53: 1172-89 (2010) 1
Institutions 15 ▿
- [Northern Illinois University] 4
- [University of Tromsø, Lieber Institute for Brain Development, Universit£t Heidelberg, ActivX Biosciences, Inc., Instituto de Quimica Medica] 2
- [University of Tromsø, Lieber Institute for Brain Development, Universit£t Heidelberg, ActivX Biosciences, Inc., Instituto de Quimica Medica] 2
- [University of Tromsø, Lieber Institute for Brain Development, Universit£t Heidelberg, ActivX Biosciences, Inc., Instituto de Quimica Medica] 2
- [University of Tromsø, Lieber Institute for Brain Development, Universit£t Heidelberg, ActivX Biosciences, Inc., Instituto de Quimica Medica] 2
- [University of Tromsø, Lieber Institute for Brain Development, Universit£t Heidelberg, ActivX Biosciences, Inc., Instituto de Quimica Medica] 2
- [Emory University Molecular Libraries Screening Center, The Scripps Research Institute, U.S. Army Medical Research Institute of Infectious Diseases, Institute for Cancer Research, University of California, University of California San Diego , AstraZeneca, The University of Denver and Regis University, Wyeth Research] 1
- [Emory University Molecular Libraries Screening Center, The Scripps Research Institute, U.S. Army Medical Research Institute of Infectious Diseases, Institute for Cancer Research, University of California, University of California San Diego , AstraZeneca, The University of Denver and Regis University, Wyeth Research] 1
- [Emory University Molecular Libraries Screening Center, The Scripps Research Institute, U.S. Army Medical Research Institute of Infectious Diseases, Institute for Cancer Research, University of California, University of California San Diego , AstraZeneca, The University of Denver and Regis University, Wyeth Research] 1
- [Emory University Molecular Libraries Screening Center, The Scripps Research Institute, U.S. Army Medical Research Institute of Infectious Diseases, Institute for Cancer Research, University of California, University of California San Diego , AstraZeneca, The University of Denver and Regis University, Wyeth Research] 1
- [Emory University Molecular Libraries Screening Center, The Scripps Research Institute, U.S. Army Medical Research Institute of Infectious Diseases, Institute for Cancer Research, University of California, University of California San Diego , AstraZeneca, The University of Denver and Regis University, Wyeth Research] 1
- [Emory University Molecular Libraries Screening Center, The Scripps Research Institute, U.S. Army Medical Research Institute of Infectious Diseases, Institute for Cancer Research, University of California, University of California San Diego , AstraZeneca, The University of Denver and Regis University, Wyeth Research] 1
- [Emory University Molecular Libraries Screening Center, The Scripps Research Institute, U.S. Army Medical Research Institute of Infectious Diseases, Institute for Cancer Research, University of California, University of California San Diego , AstraZeneca, The University of Denver and Regis University, Wyeth Research] 1
- [Emory University Molecular Libraries Screening Center, The Scripps Research Institute, U.S. Army Medical Research Institute of Infectious Diseases, Institute for Cancer Research, University of California, University of California San Diego , AstraZeneca, The University of Denver and Regis University, Wyeth Research] 1
- [Emory University Molecular Libraries Screening Center, The Scripps Research Institute, U.S. Army Medical Research Institute of Infectious Diseases, Institute for Cancer Research, University of California, University of California San Diego , AstraZeneca, The University of Denver and Regis University, Wyeth Research] 1
Affinity: 1.0E+2 to 1.0E+6 nM▿
- Ki 1
- IC50 24
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1