null
SMILES OC1C=CC(Cc2ccccc2)=CN1O
InChI Key InChIKey=DPMFXHXIAGAGNR-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50434276
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College of Medicine
Curated by ChEMBL
Baylor College of Medicine
Curated by ChEMBL
Affinity DataKi: 120nMAssay Description:Inhibition of human IDH1 R132C mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumptionMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College of Medicine
Curated by ChEMBL
Baylor College of Medicine
Curated by ChEMBL
Affinity DataKi: 8.20E+3nMAssay Description:Inhibition of human IDH1 R132H mutant expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumptionMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College of Medicine
Curated by ChEMBL
Baylor College of Medicine
Curated by ChEMBL
Affinity DataKi: 1.23E+4nMAssay Description:Inhibition of wild type human IDH1 expressed in Escherichia coli BL21-CodonPlus assessed as reduction in NADPH consumptionMore data for this Ligand-Target Pair
TargetIsocitrate dehydrogenase [NADP] cytoplasmic(Homo sapiens (Human))
Baylor College of Medicine
Curated by ChEMBL
Baylor College of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of IDH1 R132C mutant in human HT1080 cells assessed as reduction in D2HG production incubated for 48 hrs by HPLC-MS methodMore data for this Ligand-Target Pair