BindingDB

null

SMILES Oc1ccc(cc1O)-c1oc2c(O)c(O)cc(O)c2c(=O)c1O

InChI Key InChIKey=YRRAGUMVDQQZIY-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 26655

Microtubule-associated protein tau(Homo sapiens (Human))
Tokyo Institute of Technology

Curated by ChEMBL

BDBM26655(2-(3,4-dihydroxyphenyl)-3,5,7,8-tetrahydroxy-4H-ch...)copy SMILEScopy InChI

IC50: 3.00E+3nMAssay Description:Inhibition of His-tagged human brain tau 3R MBD aggregation after 16 hrs by thioflavin T fluorescence methodMore data for this Ligand-Target Pair

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Details Article
BindingDB Entry DOI: 10.7270/Q2RJ4M4QPubMed

Targets 12 ▿
- Co-chaperonin GroES 2
- Serine/threonine-protein kinase pim-1 2
- Death-associated protein kinase 1 1
- 60 kDa heat shock protein, mitochondrial 1
- Fructose-1,6-bisphosphatase 1 1
- Aromatase 1
- Thiosulfate sulfurtransferase 1
- Aurora kinase B 1
- Chaperonin GroEL 1
- Solute carrier organic anion transporter family member 2B1 1
- Microtubule-associated protein tau 1
- Sialidase 1
Publications 9 ▿
- Bioorg Med Chem Lett 29: 1106-1112 (2019) 5
- Bioorg Med Chem 16: 8466-70 (2008) 1
- Eur J Med Chem 85: 228-34 (2014) 1
- J Med Chem 58: 7400-8 (2015) 1
- Bioorg Med Chem 17: 6816-23 (2009) 1
- J Nat Prod 83: 1541-1552 (2020) 1
- Mol Cancer Ther 6: 163-72 (2007) 1
- Chem Biol Drug Des 85: 574-85 (2015) 1
- Bioorg Med Chem 15: 6463-73 (2007) 1
Institutions 9 ▿
- [Indiana University School of Medicine] 5
- [Loma Linda University, Loma Linda University School of Medicine, Tokyo Institute of Technology, University of Porto, Konkuk University, King's College London, University of Toyama, Korea Research Institute of Bioscience and Biotechnology] 1
- [Loma Linda University, Loma Linda University School of Medicine, Tokyo Institute of Technology, University of Porto, Konkuk University, King's College London, University of Toyama, Korea Research Institute of Bioscience and Biotechnology] 1
- [Loma Linda University, Loma Linda University School of Medicine, Tokyo Institute of Technology, University of Porto, Konkuk University, King's College London, University of Toyama, Korea Research Institute of Bioscience and Biotechnology] 1
- [Loma Linda University, Loma Linda University School of Medicine, Tokyo Institute of Technology, University of Porto, Konkuk University, King's College London, University of Toyama, Korea Research Institute of Bioscience and Biotechnology] 1
- [Loma Linda University, Loma Linda University School of Medicine, Tokyo Institute of Technology, University of Porto, Konkuk University, King's College London, University of Toyama, Korea Research Institute of Bioscience and Biotechnology] 1
- [Loma Linda University, Loma Linda University School of Medicine, Tokyo Institute of Technology, University of Porto, Konkuk University, King's College London, University of Toyama, Korea Research Institute of Bioscience and Biotechnology] 1
- [Loma Linda University, Loma Linda University School of Medicine, Tokyo Institute of Technology, University of Porto, Konkuk University, King's College London, University of Toyama, Korea Research Institute of Bioscience and Biotechnology] 1
- [Loma Linda University, Loma Linda University School of Medicine, Tokyo Institute of Technology, University of Porto, Konkuk University, King's College London, University of Toyama, Korea Research Institute of Bioscience and Biotechnology] 1
Affinity: 3.3E+2 to 2.5E+5 nM▿
- IC50 14
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1