BindingDB

null

SMILES FC(F)(F)c1cccc(c1)N1CCNCC1

InChI Key InChIKey=KKIMDKMETPPURN-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50007406

Serotonin 2 (5-HT2) receptor(RAT)
TBA

Curated by ChEMBL

BDBM50007406(1-(3-(trifluoromethyl)phenyl)piperazine | 1-(3-Tri...)copy SMILEScopy InChI

Ki: 160nMAssay Description:Displacement of [3H]ketanserin from 5-hydroxytryptamine 2 receptor of rat cortexMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
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Details
BindingDB Entry DOI: 10.7270/Q2Z03BCHPubMed

Targets 21 ▿
- 5-hydroxytryptamine receptor 1B 15
- 5-hydroxytryptamine receptor 2C 7
- 5-hydroxytryptamine receptor 1A 7
- 5-hydroxytryptamine receptor 2A 6
- 5-hydroxytryptamine receptor 1D 6
- 5-hydroxytryptamine receptor 2B 5
- Serotonin 2 (5-HT2) receptor 4
- 5-hydroxytryptamine receptor 5A 3
- 5-hydroxytryptamine receptor 1F 3
- 5-hydroxytryptamine receptor 6 3
- 5-hydroxytryptamine receptor 1E 3
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 2
- 5-hydroxytryptamine 1D receptor 2
- 5-hydroxytryptamine receptor 5B 2
- 5-hydroxytryptamine receptor 7 2
- Sigma non-opioid intracellular receptor 1 1
- Neuronal acetylcholine receptor subunit alpha-4/beta-2 1
- Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor 1
- D(2) dopamine receptor 1
- D(1A) dopamine receptor 1
- 5-hydroxytryptamine receptor 3A/3B/3C/3D/3E 1
- ...
Publications 32 ▿
- Neuropharmacology 33: 275-317 (1994) 17
- J Med Chem 32: 1052-6 (1989) 7
- J Med Chem 33: 2087-93 (1990) 5
- J Med Chem 30: 1-12 (1987) 4
- Synapse 35: 144-50 (2000) 4
- Br J Pharmacol 128: 13-20 (1999) 3
- Naunyn Schmiedebergs Arch Pharmacol 370: 114-23 (2004) 3
- Proc Natl Acad Sci U S A 89: 3630-4 (1992) 3
- J Pharmacol Exp Ther 276: 720-7 (1996) 2
- J Med Chem 28: 945-8 (1985) 2
- Mol Pharmacol 43: 313-9 (1993) 2
- J Biol Chem 268: 18200-4 (1993) 2
- J Neurochem 53: 465-71 (1989) 2
- Ann N Y Acad Sci 861: 140-5 (1998) 2
- EMBO J 11: 4779-86 (1992) 1
- Mol Pharmacol 42: 180-5 (1992) 1
- Comp Biochem Physiol C, Pharmacol Toxicol Endocrinol 117: 19-24 (1997) 1
- J Med Chem 39: 126-34 (1996) 1
- J Med Chem 31: 1968-71 (1988) 1
- J Med Chem 39: 4439-50 (1996) 1
- J Med Chem 32: 720-7 (1989) 1
- J Med Chem 34: 3360-5 (1992) 1
- J Med Chem 29: 630-4 (1986) 1
- J Med Chem 39: 4017-26 (1996) 1
- Mol Pharmacol 40: 143-8 (1991) 1
- J Neurochem 66: 47-56 (1996) 1
- Proc Natl Acad Sci U S A 90: 408-12 (1993) 1
- J Pharmacol Exp Ther 260: 614-26 (1992) 1
- J Med Chem 44: 3946-55 (2001) 1
- Mol Pharmacol 44: 229-36 (1993) 1
- Biochem Biophys Res Commun 184: 752-9 (1992) 1
- Mol Pharmacol 43: 320-7 (1993) 1
Institutions 21 ▿
- [University of Alberta] 17
- [Albany Medical College] 8
- [TBA, McNeil Pharmaceutical and Janssen Research Foundation Worldwide] 7
- [TBA, McNeil Pharmaceutical and Janssen Research Foundation Worldwide] 7
- [Pfizer Inc., Synaptic Pharmaceutical Corporation] 5
- [Pfizer Inc., Synaptic Pharmaceutical Corporation] 5
- [CNRS] 4
- [National Institute of Neurological Disorders and Stroke, Vernalis Research, Virginia Commonwealth University, Cerebrus Ltd] 3
- [National Institute of Neurological Disorders and Stroke, Vernalis Research, Virginia Commonwealth University, Cerebrus Ltd] 3
- [National Institute of Neurological Disorders and Stroke, Vernalis Research, Virginia Commonwealth University, Cerebrus Ltd] 3
- [National Institute of Neurological Disorders and Stroke, Vernalis Research, Virginia Commonwealth University, Cerebrus Ltd] 3
- [Eli Lilly and Company] 2
- [Seattle Veterans Affairs Medical Center, Veterans Affairs Medical Center, CIBA-GEIGY Corporation, University of Montana, University of Texas, University of Washington, Universit£ di Firenze, Universit£ de Lausanne, Universidad Complutense] 1
- [Seattle Veterans Affairs Medical Center, Veterans Affairs Medical Center, CIBA-GEIGY Corporation, University of Montana, University of Texas, University of Washington, Universit£ di Firenze, Universit£ de Lausanne, Universidad Complutense] 1
- [Seattle Veterans Affairs Medical Center, Veterans Affairs Medical Center, CIBA-GEIGY Corporation, University of Montana, University of Texas, University of Washington, Universit£ di Firenze, Universit£ de Lausanne, Universidad Complutense] 1
- [Seattle Veterans Affairs Medical Center, Veterans Affairs Medical Center, CIBA-GEIGY Corporation, University of Montana, University of Texas, University of Washington, Universit£ di Firenze, Universit£ de Lausanne, Universidad Complutense] 1
- [Seattle Veterans Affairs Medical Center, Veterans Affairs Medical Center, CIBA-GEIGY Corporation, University of Montana, University of Texas, University of Washington, Universit£ di Firenze, Universit£ de Lausanne, Universidad Complutense] 1
- [Seattle Veterans Affairs Medical Center, Veterans Affairs Medical Center, CIBA-GEIGY Corporation, University of Montana, University of Texas, University of Washington, Universit£ di Firenze, Universit£ de Lausanne, Universidad Complutense] 1
- [Seattle Veterans Affairs Medical Center, Veterans Affairs Medical Center, CIBA-GEIGY Corporation, University of Montana, University of Texas, University of Washington, Universit£ di Firenze, Universit£ de Lausanne, Universidad Complutense] 1
- [Seattle Veterans Affairs Medical Center, Veterans Affairs Medical Center, CIBA-GEIGY Corporation, University of Montana, University of Texas, University of Washington, Universit£ di Firenze, Universit£ de Lausanne, Universidad Complutense] 1
- [Seattle Veterans Affairs Medical Center, Veterans Affairs Medical Center, CIBA-GEIGY Corporation, University of Montana, University of Texas, University of Washington, Universit£ di Firenze, Universit£ de Lausanne, Universidad Complutense] 1
Affinity: 2.3 to 1.0E+4 nM▿
- Ki 70
- IC50 6
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1