null
SMILES C[C@H](N1CC[C@@](CCCNS(C)(=O)=O)(OC1=O)c1ccc(F)cc1)c1ccc(cc1)-c1ccc(F)cc1F
InChI Key InChIKey=SDPGWJVXVCTHJY-HMILPKGGSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 50353395
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
US Patent
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
US Patent
Affinity DataIC50: 1.79nMAssay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
US Patent
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
US Patent
Affinity DataIC50: 53.5nMAssay Description:The inhibition assay using 11β-HSD1.More data for this Ligand-Target Pair
TargetCytochrome P450 2C9(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
US Patent
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International GmbH
US Patent
Affinity DataIC50: 3.60E+3nMAssay Description:The inhibition of recombinant CYP2C9 by compounds of the invention was measured using a commercial kit from Invitrogen (cat #2859).More data for this Ligand-Target Pair