BindingDB

null

SMILES NC(N)=S

InChI Key InChIKey=UMGDCJDMYOKAJW-UHFFFAOYSA-N

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50229993

Urease(Canavalia ensiformis (Jack bean) (Horse bean))
Universiti Teknologi MARA (UiTM), Puncak Alam Campus

BDBM50229993(2-thiourea | CHEMBL260876 | Thiocarbamid | Thiohar...)copy SMILEScopy InChI

IC50: 1.95E+4nMpH: 6.8 T: 2°CAssay Description:To understand the binding modes of the compounds given in Table 1, all ligands were docked into the binding site of Urease enzyme. The top ranked con...More data for this Ligand-Target Pair

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Details Article
BindingDB Entry DOI: 10.7270/Q20G3HXWPubMed

Targets 7 ▿
- Urease 30
- Urease subunit alpha 2
- Serine-protein kinase ATM 1
- Alcohol dehydrogenase E/S chain 1
- Urease [D459Y,K653P] 1
- Serine/threonine-protein kinase ATR 1
- Urease subunit beta 1
Publications 29 ▿
- Eur J Med Chem 74: 314-23 (2014) 2
- Proc Natl Acad Sci USA 104: 20523-8 (2007) 2
- Eur J Med Chem 46: 5473-9 (2011) 2
- US Patent US9447057 (2016) 1
- Bioorg Chem 64: 85-96 (2016) 1
- Chem Biol Drug Des 87: 434-43 (2016) 1
- J Enzyme Inhib Med Chem 26: 480-4 (2011) 1
- Eur J Med Chem 87: 657-61 (2014) 1
- Eur J Med Chem 102: 464-70 (2015) 1
- J Enzyme Inhib Med Chem 25: 296-9 (2010) 1
- Bioorg Med Chem 26: 3791-3804 (2018) 1
- Bioorg Med Chem 26: 152-160 (2018) 1
- J Enzyme Inhib Med Chem 24: 437-46 (2009) 1
- Bioorg Med Chem 23: 7211-8 (2015) 1
- Bioorg Med Chem Lett 25: 3285-9 (2015) 1
- J Enzyme Inhib Med Chem 24: 151-6 (2009) 1
- J Enzyme Inhib Med Chem 25: 572-6 (2010) 1
- Eur J Med Chem 70: 487-96 (2013) 1
- Bioorg Chem 66: 80-7 (2016) 1
- Bioorg Chem 66: 111-6 (2016) 1
- J Enzyme Inhib Med Chem 28: 1316-23 (2013) 1
- J Med Chem 26: 916-22 (1983) 1
- Bioorg Chem 63: 123-31 (2015) 1
- Bioorg Med Chem 24: 4452-4463 (2016) 1
- Bioorg Med Chem Lett 27: 3014-3018 (2017) 1
- Bioorg Med Chem 23: 6049-58 (2015) 1
- Eur J Med Chem 69: 622-31 (2013) 1
- Chem Biol Drug Des 85: 225-30 (2015) 1
- Eur J Med Chem 67: 230-42 (2013) 1
Institutions 22 ▿
- [Quaid-i-Azam University] 5
- [COMSATS Institute of Information Technology] 3
- [TBA, University Karachi, Karadeniz Technical University, University of Oxford] 2
- [TBA, University Karachi, Karadeniz Technical University, University of Oxford] 2
- [TBA, University Karachi, Karadeniz Technical University, University of Oxford] 2
- [TBA, University Karachi, Karadeniz Technical University, University of Oxford] 2
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
- [Hazara University, The Islamia University of Bahawalpur, University of the Punjab, Solapur University, Khyber Medical College, Bahauddin Zakariya University, Universiti Teknologi MARA Puncak Alam Campus, Kongju National University, Universiti Teknologi MARA (UiTM), University of Mysore, University of Karachi, Department of Chemistry, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey. Electronic address: emre.mentese@erdogan.edu.tr., Universiti Teknologi MARA (UiTM), Puncak Alam Campus, Imam Abdulrahman Bin Faisal University, University of Peshawar, Quaid-I-Azam University] 1
Affinity: 2.0E+2 to 4.2E+7 nM▿
- Ki 6
- IC50 33
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1