null
SMILES COc1cc(nc(c1)-c1cc(NC(=O)c2cccc(c2)C(F)(F)F)ccc1C)N1CCOCC1
InChI Key InChIKey=DCKPXKUYFVTZND-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 3 hits for monomerid = 202843
Affinity DataIC50: 2.19nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase [1-324](Homo sapiens (Human))
Novartis AG
US Patent
Novartis AG
US Patent
Affinity DataIC50: 0.621nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E](Homo sapiens (Human))
Novartis AG
US Patent
Novartis AG
US Patent
Affinity DataIC50: 0.403nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair