BindingDB

null

SMILES Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1

InChI Key InChIKey=QQUXFYAWXPMDOE-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 7266

Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
CNRS

BDBM7266(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)copy SMILEScopy InChI

IC50: 400nMpH: 7.2 T: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2CR5RJSPubMed

Cyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
CNRS

BDBM7266(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)copy SMILEScopy InChI

IC50: 850nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2CR5RJSPubMed

Glycogen synthase kinase-3 beta(Rattus norvegicus (rat))
CNRS

BDBM7266(14-bromo-8,18-diazatetracyclo[9.7.0.0^{2,7}.0^{12,...)copy SMILEScopy InChI

IC50: 23nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/[gamma-32P] ATP. 32P...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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BindingDB Entry DOI: 10.7270/Q2CR5RJSPubMed

Targets 32 ▿
- Glycogen synthase kinase-3 beta 9
- Platelet-derived growth factor receptor alpha/beta 8
- Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 4
- Mitogen-activated protein kinase 1 3
- Mitogen-activated protein kinase 3 3
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 3
- Cyclin-dependent kinase 5 activator 1 3
- Cyclin-dependent kinase 5 activator 1 [99-307] 2
- Tyrosine-protein kinase Lck 2
- Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B 2
- Dual specificity protein kinase CLK1 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 2
- Proto-oncogene tyrosine-protein kinase Src 2
- MO15-related protein kinase Pfmrk 2
- Insulin receptor 2
- Serine/threonine-protein kinase PLK1 1
- Ninein 1
- Steroidogenic factor 1 1
- Tyrosine-protein kinase ABL1 1
- Replicase polyprotein 1ab 1
- Casein kinase I isoform alpha 1
- Glycogen synthase kinase 3 1
- Casein kinase II subunit alpha 3 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Nuclear receptor subfamily 0 group B member 1 1
- Cyclin-dependent kinase 2 1
- Cyclin-A2/Cyclin-dependent kinase 2 1
- Cyclin-dependent kinase 1 1
- Cyclin-T1/Cyclin-dependent kinase 9 1
- NAD-dependent protein deacetylase sirtuin-2 1
- Vascular endothelial growth factor receptor 2 1
- Casein kinase II subunit alpha 1
- ...
Publications 21 ▿
- Bioorg Med Chem Lett 20: 4940-4 (2010) 8
- Proc Natl Acad Sci USA 104: 20523-8 (2007) 6
- Eur J Biochem 267: 5983-94 (2000) 3
- Biochem J 371: 199-204 (2003) 3
- Bioorg Med Chem Lett 14: 413-6 (2004) 3
- J Med Chem 53: 2433-42 (2010) 3
- Eur J Med Chem 45: 335-42 (2010) 2
- J Med Chem 46: 876-9 (2003) 2
- Trends Pharmacol Sci 25: 471-80 (2004) 2
- J Med Chem 47: 5418-26 (2004) 1
- Bioorg Med Chem Lett 10: 567-9 (2000) 1
- J Med Chem 49: 7307-16 (2006) 1
- J Med Chem 42: 2909-19 (1999) 1
- PubChem Bioassay (2013) 1
- Eur J Med Chem 45: 4316-30 (2010) 1
- J Med Chem 46: 3877-82 (2003) 1
- Eur J Med Chem 142: 244-265 (2017) 1
- J Med Chem 60: 8482-8514 (2017) 1
- PubChem Bioassay (2013) 1
- J Med Chem 51: 2196-207 (2008) 1
- Bioorg Med Chem Lett 24: 1532-7 (2014) 1
Institutions 17 ▿
- [Trinity College] 8
- [Technische Universitat Braunschweig, University of Oxford] 6
- [Technische Universitat Braunschweig, University of Oxford] 6
- [CNRS, University of Dundee, Technische Universit£t Braunschweig] 3
- [CNRS, University of Dundee, Technische Universit£t Braunschweig] 3
- [CNRS, University of Dundee, Technische Universit£t Braunschweig] 3
- [Universität Hamburg, Martin-Luther-University Halle-Wittenberg, The Rockefeller University, The Scripps Research Institute Molecular Screening Center] 2
- [Universität Hamburg, Martin-Luther-University Halle-Wittenberg, The Rockefeller University, The Scripps Research Institute Molecular Screening Center] 2
- [Universität Hamburg, Martin-Luther-University Halle-Wittenberg, The Rockefeller University, The Scripps Research Institute Molecular Screening Center] 2
- [Universität Hamburg, Martin-Luther-University Halle-Wittenberg, The Rockefeller University, The Scripps Research Institute Molecular Screening Center] 2
- [Institute of Research, University of Jordan, Northwestern University, Babasaheb Bhimrao Ambedkar University, Novartis Institutes for BioMedical Research, Walter Reed Army Institute of Research, Albert-Ludwigs-Universität Freiburg] 1
- [Institute of Research, University of Jordan, Northwestern University, Babasaheb Bhimrao Ambedkar University, Novartis Institutes for BioMedical Research, Walter Reed Army Institute of Research, Albert-Ludwigs-Universität Freiburg] 1
- [Institute of Research, University of Jordan, Northwestern University, Babasaheb Bhimrao Ambedkar University, Novartis Institutes for BioMedical Research, Walter Reed Army Institute of Research, Albert-Ludwigs-Universität Freiburg] 1
- [Institute of Research, University of Jordan, Northwestern University, Babasaheb Bhimrao Ambedkar University, Novartis Institutes for BioMedical Research, Walter Reed Army Institute of Research, Albert-Ludwigs-Universität Freiburg] 1
- [Institute of Research, University of Jordan, Northwestern University, Babasaheb Bhimrao Ambedkar University, Novartis Institutes for BioMedical Research, Walter Reed Army Institute of Research, Albert-Ludwigs-Universität Freiburg] 1
- [Institute of Research, University of Jordan, Northwestern University, Babasaheb Bhimrao Ambedkar University, Novartis Institutes for BioMedical Research, Walter Reed Army Institute of Research, Albert-Ludwigs-Universität Freiburg] 1
- [Institute of Research, University of Jordan, Northwestern University, Babasaheb Bhimrao Ambedkar University, Novartis Institutes for BioMedical Research, Walter Reed Army Institute of Research, Albert-Ludwigs-Universität Freiburg] 1
Affinity: 9 to 1.0E+6 nM▿
- Ki 3
- IC50 63
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1