null

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(nc(n1)N1CCOCC1)N1CCCOCC1

InChI Key InChIKey=WQNJLMVKMKGYHJ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 202704   

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202704(US10245267, Example 50 | US10709712, Example 50 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2280BP3US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202704(US10245267, Example 50 | US10709712, Example 50 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.13nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2280BP3US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202704(US10245267, Example 50 | US10709712, Example 50 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2280BP3US Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202704(US10245267, Example 50 | US10709712, Example 50 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2280BP3US Patent