null

SMILES C[C@@H]1Cc2c(ccc3[nH]ncc23)[C@H](N1CC(F)F)c1ccc(NC2CN(CCCF)C2)cn1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 300959   

TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM300959(6-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8,9-...)copy SMILES
Affinity DataIC50: 4.10nMAssay Description:The assay principle is that ER alpha-LBD (GST) is added to a fluorescent ligand to form a receptor/fluorophore complex. A terbium-labelled anti-GST a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P55QJ9US Patent
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM300959(6-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8,9-...)copy SMILES
Affinity DataIC50: 0.330nMAssay Description:The ability of compounds to down-regulate Estrogen Receptor (ER) numbers was assessed in a cell based immuno-fluorescence assay using the MCF-7 human...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P55QJ9US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM300959(6-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8,9-...)copy SMILES
Affinity DataIC50: 2.80E+4nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2P55QJ9US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM300959(6-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8,9-...)copy SMILES
Affinity DataIC50: 4.10nMAssay Description:hERG (human ether go go-related gene) potassium channels are essential for normal electrical activity in the heart. Arrhythmia can be induced by a bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4SX5US Patent
TargetEstrogen receptor [307-554](Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM300959(6-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8,9-...)copy SMILES
Affinity DataIC50: 4.10nMAssay Description:The assay was performed as follows with all reagent additions carried out using the Beckman Coulter BioRAPTR FRD microfluidic workstation:1. Acoustic...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2BR8W8PUS Patent
TargetEstrogen receptor [307-554](Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM300959(6-((6S,8R)-7-(2,2-difluoroethyl)-8-methyl-6,7,8,9-...)copy SMILES
Affinity DataIC50: 2.80E+4nMAssay Description:ER: The ability of compounds to bind to isolated Estrogen Receptor Alpha Ligand binding domain (ER alpha-LBD (GST)) was assessed in competition assay...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28S4SX5US Patent