null
SMILES C[C@H](N1CC[C@@](CCCO)(OC1=O)c1ccccc1)c1ccc(cc1)-c1ccc(=O)n(C)c1
InChI Key InChIKey=BUIPWQYAVGFZFQ-CCLHPLFOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 107656
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH
US Patent
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH
US Patent
Affinity DataIC50: 1.44nMAssay Description:The inhibition of a microsomal preparation of 11β-HSD1 by compounds of the invention was measured essentially as previously described (K. Solly,...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH
US Patent
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH
US Patent
Affinity DataIC50: 3.42nMAssay Description:Inhibition assay using 11β-HSD1 in the presence of 50% human plasma. More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH
US Patent
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH
US Patent
Affinity DataIC50: 5.70nMAssay Description:Inhibition of 11beta-HSD1 in human omental adipocytes using [3H]cortisone as substrate preincubated for 1 hr followed by substrate addition measured ...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH
US Patent
Vitae Pharmaceuticals, Inc.; Boehringer Ingelheim International, GmbH
US Patent
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cell microsomes using [3H]cortisone as substrate preincubated with substrate for 10 mins followed by...More data for this Ligand-Target Pair