null

SMILES C[C@H]1CNCCc2ccc(Cl)cc12

InChI Key InChIKey=XTTZERNUQAFMOF-QMMMGPOBSA-N

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50161646   

Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Agonist activity at 5-HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V12656PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataKi:  174nMAssay Description:Displacement of [3H]DOI from recombinant human 5HT2B receptor expressed in HEK293T cell membranes after 1 hr by beta scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C71SKPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataKi:  174nMAssay Description:Agonist activity at 5-HT2BR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20868KKPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataKi:  189nMAssay Description:Displacement of [3H]LSD from human 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81R3PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataKi:  220nMAssay Description:Displacement of [125I]-1,4-Iodanyl-2,5-dimethoxyphenyl)propan-2amine from 5HT2B receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28W3HT5PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  1.00E+3nMAssay Description:Effective concentration towards 5-hydroxytryptamine 2C receptors transfected in HEK-293 cells was determined by measuring [3H]-phosphoinositol releas...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21R6Q0GPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  478nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC4181PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  943nMAssay Description:Agonist activity at human recombinant 5HT2B receptor expressed in HEK293 cells assessed as [3H]inositol incorporation after 2 hrs by TopCount scintil...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BC4181PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  219nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81R3PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  328nMAssay Description:Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9Z4PPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  328nMAssay Description:Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28C9Z4PPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  943nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells by inositol phosphate accumulation assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HD7VZZPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  433nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6G5CPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  437nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in Flp-IN HEK293 cells assessed as induction of calcium flux measured every second for 5 mins by ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MK6G5CPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  794nMAssay Description:Agonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as intracellular IP3 accumulationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q211BPubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  79nMAssay Description:Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0JG8PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  80nMAssay Description:Agonist activity at recombinant human 5HT2B receptor expressed in Flp-In-293 cells assessed as increase in calcium influx measured for 300 secs by Fl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0JG8PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  437nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28P6455PubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50161646((1R)-8-chloro-2,3,4,5-tetrahydro-1-methyl-1H-3-ben...)copy SMILEScopy InChI
Affinity DataEC50:  433nMAssay Description:Agonist activity at human 5-HT2B receptor expressed in human Flp-In-293 cells assessed as induction of calcium flux incubated for 1 hr by Fluo-4 dire...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q28P6455PubMed