null
SMILES CC1(C)c2[nH]c3cc(ccc3c2C(=O)c2ccc(cc12)C1CCN(CC2CCOCC2)CC1)C#N
InChI Key InChIKey=VWCZORWQNKCYGE-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50187716
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of N-terminal His6-tagged recombinant human ALK (1058 residues) expressed in insect Sf21 cells using poly(Glu,Tyr)4:1 as substrate incubat...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of gatekeeper ALK L1196M mutant (unknown origin) using poly (Glu, Tyr)4:1 substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of ALK expressed in human NCI-H3122 cells assessed as cell growth inhibition after 72 hrs by SRB/CCK-8 assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant ALK L1196M mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant ALK C1156Y mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of recombinant ALK F1174L mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 8.10nMAssay Description:Inhibition of recombinant ALK G1269A mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 7.60nMAssay Description:Inhibition of recombinant ALK R1275Q mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 38nMAssay Description:Inhibition of recombinant ALK T1151ins mutant (unknown origin) using poly(Glu,Tyr)4:1 as substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Chinese Academy of Sciences
Curated by ChEMBL
Chinese Academy of Sciences
Curated by ChEMBL
Affinity DataIC50: 3.40nMAssay Description:Inhibition of recombinant ALK (unknown origin) using poly (Glu, Tyr)4:1 substrate incubated for 60 mins by ELISAMore data for this Ligand-Target Pair