BindingDB

null

SMILES Oc1ccc(\C=C\C(=O)c2ccc(O)cc2O)cc1

InChI Key InChIKey=DXDRHHKMWQZJHT-FPYGCLRLSA-N

PDB links: 5 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50042944

Aldo-keto reductase family 1 member B1(Homo sapiens (Human))
King's College London

Curated by ChEMBL

BDBM50042944((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...)copy SMILEScopy InChI

IC50: 320nMAssay Description:Inhibition of human recombinant aldose reductase using D-glyceraldehyde as substrate preincubated for 10 mins before substrate addition measured for ...More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

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KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2639Q5VPubMed

Aldo-keto reductase family 1 member B1(Rattus norvegicus)TBA

BDBM50042944((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...)copy SMILEScopy InChI

IC50: 400nMAssay Description:Inhibition of Rattus norvegicus (rat) lens aldose reductaseMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD GoogleScholar

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KEGG MMDB PC cid PC sid PDB Patents Similars

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BindingDB Entry DOI: 10.7270/Q2XP77VN

Targets 30 ▿
- Neuraminidase 5
- Beta-secretase 1 3
- Integrase 2
- Polyunsaturated fatty acid 5-lipoxygenase 2
- Tyrosine-protein phosphatase non-receptor type 1 2
- Amine oxidase [flavin-containing] A 2
- Aldo-keto reductase family 1 member B1 2
- NACHT, LRR and PYD domains-containing protein 3 2
- Estrogen receptor 1
- Tyrosyl-DNA phosphodiesterase 1 1
- Amine oxidase [flavin-containing] B 1
- Amyloid-beta precursor protein 1
- Collagenase 3 1
- Bcl-2-like protein 11 1
- Matrix metalloproteinase-9 1
- 17-beta-hydroxysteroid dehydrogenase type 2 1
- 17-beta-hydroxysteroid dehydrogenase type 1 1
- Neuronal acetylcholine receptor subunit alpha-7 1
- Aromatase 1
- Xanthine dehydrogenase/oxidase 1
- Protein disulfide-isomerase 1
- Proteasome subunit beta type-5 1
- 72 kDa type IV collagenase 1
- Prostaglandin G/H synthase 1/2 1
- Estrogen receptor beta 1
- Stromelysin-1 1
- Interstitial collagenase 1
- Sialidase 1
- Probable global transcription activator SNF2L2 1
- Matrilysin 1
Publications 21 ▿
- Bioorg Med Chem Lett 21: 294-8 (2011) 6
- J Nat Prod 80: 965-974 (2017) 5
- Bioorg Med Chem Lett 23: 4985-9 (2013) 2
- J Med Chem 36: 3904-9 (1994) 2
- Bioorg Med Chem Lett 30: (2020) 1
- Bioorg Med Chem 20: 1251-8 (2012) 1
- Eur J Med Chem 167: 291-311 (2019) 1
- Eur J Med Chem 86: 724-39 (2014) 1
- Bioorg Med Chem Lett 26: 4599-4605 (2016) 1
- Bioorg Med Chem Lett 27: 3602-3606 (2017) 1
- J Enzyme Inhib Med Chem 26: 643-8 (2011) 1
- Bioorg Med Chem Lett 27: 3123-3126 (2017) 1
- Bioorg Med Chem 26: 1653-1664 (2018) 1
- Eur J Med Chem 66: 22-31 (2013) 1
- J Med Chem 41: 3948-60 (1998) 1
- PubChem Bioassay (2010) 1
- J Nat Prod 69: 1572-6 (2006) 1
- Bioorg Med Chem Lett 19: 5155-7 (2009) 1
- J Med Chem 45: 841-52 (2002) 1
- Bioorg Med Chem 28: (2020) 1
- PubChem Bioassay (2013) 1
Institutions 18 ▿
- [Chosun University] 6
- [University of Basel] 5
- [North-West University] 3
- [Soochow University, Sun Yat-sen University, Tokushima Bunri University] 2
- [Soochow University, Sun Yat-sen University, Tokushima Bunri University] 2
- [Soochow University, Sun Yat-sen University, Tokushima Bunri University] 2
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
- [Ewha Womans University, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Instituto de Qu£mica M£dica (IQM-CSIC), Universit£ di Roma"La Sapienza", Institute, University of Tennessee Health Science Center, King's College London, Guangxi Medical University, Institute of Agricultural and Food Biotechnology, The Scripps Research Institute Molecular Screening Center, Broad Institute, Korea Research Institute of Bioscience and Biotechnology] 1
Affinity: 8 to 3.5E+5 nM▿
- Ki 1
- IC50 38
- EC50 3
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1