BindingDB

null

SMILES COc1cc(C=CC(=O)CC(=O)C=Cc2ccc(O)c(OC)c2)ccc1O

InChI Key InChIKey=VFLDPWHFBUODDF-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50067040

Alkaline phosphatase, tissue-nonspecific isozyme(Homo sapiens (Human))
Burnham Center for Chemical Genomics

Curated by PubChem BioAssay

BDBM50067040(((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-hept...)copy SMILEScopy InChI

IC50: 1.00E+5nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Purchase CHEMBL PC cid PC sid PDB Patents Similars

Details
BindingDB Entry DOI: 10.7270/Q2H130G1PCBioAssay

Targets 69 ▿
- Integrase 9
- Polyunsaturated fatty acid 5-lipoxygenase 6
- Prostaglandin G/H synthase 1 5
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 4
- 11-beta-hydroxysteroid dehydrogenase 1 4
- Amyloid-beta precursor protein 4
- Prostaglandin G/H synthase 2 3
- 17-beta-hydroxysteroid dehydrogenase type 3 3
- Signal transducer and activator of transcription 3 3
- Histone acetyltransferase p300 3
- Multidrug resistance protein CDR1 2
- Histone deacetylase 2
- Intestinal-type alkaline phosphatase 2
- Beta-secretase 1 2
- Protease 2
- Prostaglandin E synthase 2
- Neuraminidase 2
- Tissue factor 2
- Nitric oxide synthase, inducible 2
- Acetylcholinesterase 2
- Lactoylglutathione lyase 2
- Aminopeptidase N 2
- Beta-lactamase 1
- Carbonic anhydrase 12 1
- Carbonic anhydrase 1 1
- Carbonic anhydrase 15 1
- Carbonic anhydrase 14 1
- Protein kinase C delta type 1
- Carbonic anhydrase 13 1
- Potassium two pore domain channel subfamily K member 2 1
- Vitamin D3 receptor 1
- Histone acetyltransferase KAT5 1
- RmtA 1
- Epidermal growth factor receptor 1
- Nuclear factor erythroid 2-related factor 2 1
- Cell division protein FtsZ 1
- Protein kinase C epsilon type 1
- DNA topoisomerase 2-alpha 1
- Polyunsaturated fatty acid lipoxygenase ALOX15 1
- Cytochrome P450 1A2 1
- Protein arginine N-methyltransferase 1 [11-371] 1
- Cytochrome P450 2C9 1
- Anthrax toxin receptor 2 1
- Carbonic anhydrase 5A, mitochondrial 1
- Pancreatic triacylglycerol lipase 1
- Cytochrome P450 3A4 1
- Intestinal-type alkaline phosphatase 1 1
- Orphan methyltransferase M.SssI 1
- Tubulin alpha chain 1
- Toll-like receptor 4 1
- Replicase polyprotein 1ab 1
- Alkaline phosphatase, germ cell type 1
- Toll-like receptor 9 1
- Protein kinase C theta type 1
- Collagenase 3 1
- Carbonic anhydrase 5B, mitochondrial 1
- Matrix metalloproteinase-9 1
- Serine/threonine-protein kinase 33 1
- Alkaline phosphatase, tissue-nonspecific isozyme 1
- Carbonic anhydrase 6 1
- Carbonic anhydrase 7 1
- Carbonic anhydrase 9 1
- Carbonic anhydrase 2 1
- Lipoxygenase 1
- Carbonic anhydrase 3 1
- Cytochrome P450 2D6 1
- Carbonic anhydrase 4 1
- Cytochrome P450 2B6 1
- Enoyl-[acyl-carrier-protein] reductase [NADH] FabI 1
- ...
Publications 50 ▿
- Bioorg Med Chem Lett 20: 5050-3 (2010) 13
- J Med Chem 57: 5638-48 (2014) 11
- Eur J Med Chem 43: 1621-31 (2008) 5
- Bioorg Med Chem 20: 6040-7 (2012) 4
- Bioorg Med Chem Lett 23: 4362-6 (2013) 4
- Proc Natl Acad Sci USA 104: 20523-8 (2007) 3
- Bioorg Med Chem 18: 1591-8 (2010) 3
- J Nat Prod 72: 2019-23 (2009) 3
- Bioorg Med Chem 22: 4151-61 (2014) 3
- Bioorg Med Chem Lett 20: 2549-51 (2010) 3
- Bioorg Med Chem Lett 21: 1612-6 (2011) 2
- Bioorg Med Chem Lett 23: 4948-52 (2013) 2
- Bioorg Med Chem 22: 6047-52 (2014) 2
- Antimicrob Agents Chemother 53: 3256-65 (2009) 2
- Bioorg Med Chem 17: 5219-28 (2009) 2
- J Med Chem 40: 3057-63 (1997) 2
- Bioorg Med Chem 17: 1381-6 (2009) 2
- J Med Chem 50: 1241-53 (2007) 2
- J Nat Prod 76: 1105-12 (2013) 2
- Bioorg Med Chem 17: 1290-6 (2009) 1
- Bioorg Med Chem Lett 18: 5591-3 (2008) 1
- Eur J Med Chem 45: 4209-14 (2010) 1
- Bioorg Med Chem 19: 7228-35 (2011) 1
- Bioorg Med Chem Lett 15: 1793-7 (2005) 1
- Bioorg Med Chem 21: 62-9 (2012) 1
- Bioorg Med Chem 21: 693-702 (2013) 1
- PubChem Bioassay (2010) 1
- Bioorg Med Chem Lett 21: 1512-4 (2011) 1
- J Nat Prod 72: 1533-7 (2009) 1
- Eur J Med Chem 62: 301-10 (2013) 1
- Bioorg Med Chem Lett 20: 56-9 (2010) 1
- Bioorg Med Chem Lett 17: 1466-70 (2007) 1
- J Med Chem 57: 6513-30 (2014) 1
- J Nat Prod 78: 1593-9 (2015) 1
- J Med Chem 58: 2779-98 (2015) 1
- J Med Chem 41: 3948-60 (1998) 1
- PubChem Bioassay (2010) 1
- Bioorg Med Chem Lett 19: 706-9 (2009) 1
- PubChem Bioassay (2010) 1
- Bioorg Med Chem 21: 388-94 (2012) 1
- Bioorg Med Chem Lett 23: 2880-2 (2013) 1
- Bioorg Med Chem 17: 990-1005 (2009) 1
- Bioorg Med Chem Lett 23: 2225-9 (2013) 1
- Bioorg Med Chem 19: 1189-96 (2011) 1
- Bioorg Med Chem 22: 4784-91 (2014) 1
- J Med Chem 50: 1973-7 (2007) 1
- Bioorg Med Chem Lett 10: 1879-82 (2000) 1
- J Nat Prod 68: 985-91 (2005) 1
- PubChem Bioassay (2010) 1
- Bioorg Med Chem 20: 6739-50 (2012) 1
- ...
Institutions 43 ▿
- [Universit£ degli Studi di Firenze] 13
- [University Jena] 11
- [Vrije Universiteit] 5
- [Wenzhou Medical College, Rajiv Gandhi Centre for Biotechnology] 4
- [Wenzhou Medical College, Rajiv Gandhi Centre for Biotechnology] 4
- [Burnham Center for Chemical Genomics, University of Houston, Universiti Kebangsaan Malaysia, School of Pharmacy, National Institute of Pharmaceutical Education and Research (NIPER), University of Oxford, University of Toyama] 3
- [Burnham Center for Chemical Genomics, University of Houston, Universiti Kebangsaan Malaysia, School of Pharmacy, National Institute of Pharmaceutical Education and Research (NIPER), University of Oxford, University of Toyama] 3
- [Burnham Center for Chemical Genomics, University of Houston, Universiti Kebangsaan Malaysia, School of Pharmacy, National Institute of Pharmaceutical Education and Research (NIPER), University of Oxford, University of Toyama] 3
- [Burnham Center for Chemical Genomics, University of Houston, Universiti Kebangsaan Malaysia, School of Pharmacy, National Institute of Pharmaceutical Education and Research (NIPER), University of Oxford, University of Toyama] 3
- [Burnham Center for Chemical Genomics, University of Houston, Universiti Kebangsaan Malaysia, School of Pharmacy, National Institute of Pharmaceutical Education and Research (NIPER), University of Oxford, University of Toyama] 3
- [Burnham Center for Chemical Genomics, University of Houston, Universiti Kebangsaan Malaysia, School of Pharmacy, National Institute of Pharmaceutical Education and Research (NIPER), University of Oxford, University of Toyama] 3
- [Burnham Center for Chemical Genomics, University of Houston, Universiti Kebangsaan Malaysia, School of Pharmacy, National Institute of Pharmaceutical Education and Research (NIPER), University of Oxford, University of Toyama] 3
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [Fudan University, Sun Yat-sen University, Universit£ degli Studi di Roma La Sapienza, Institute of Science and Technology, National Cancer Institute, Central China Normal University, Chungnam National University, Shandong University, Universit£ del Piemonte Orientale, Hacettepe University, Georgia State University, Jawaharlal Nehru University] 2
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- [The Ohio State University College of Medicine and Public Health, Universit£ di Roma"La Sapienza", Uppsala University, China Pharmaceutical University, Huazhong Agricultural University, Universit£ degli Studi di Salerno, Broad Institute, Guangzhou Institute of Biomedicine and Health, Università di Roma La Sapienza, The Ohio State University, Ramkhamhaeng University, Daegu Haany University, National Institute of Pharmaceutical Education and Research, Soochow University, Florida Atlantic University, Saarland University, Arizona State University, Korea Institute of Science and Technology, UNED] 1
- ...
Affinity: 0.21 to 1.1E+6 nM▿
- Ki 18
- IC50 91
- EC50 6
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1