BindingDB

null

SMILES Cl.CN1CCN2C(C1)c1ccccc1Cc1ccccc21

InChI Key InChIKey=YNPFMWCWRVTGKJ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31005

Alpha-1A adrenergic receptor/Alpha-1B adrenergic receptor/Alpha-1D adrenergic receptor/Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

BDBM31005(2-methyl-1,2,3,4,10,14b-hexahydrodibenzo[c,f]pyraz...)copy SMILEScopy InChI

IC50: 1.20E+3nMAssay Description:In vitro binding affinity towards alpha-adreno ceptor of rat forebrain using [3H]prazosinMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase PC cid PC sid Similars

Details
BindingDB Entry DOI: 10.7270/Q2SN07ZRPubMed

Targets 30 ▿
- 5-hydroxytryptamine receptor 2A 10
- 5-hydroxytryptamine receptor 2C 8
- D(2) dopamine receptor 7
- Alpha-1A adrenergic receptor 5
- 5-hydroxytryptamine receptor 7 5
- D(3) dopamine receptor 4
- 5-hydroxytryptamine receptor 1A 4
- 5-hydroxytryptamine receptor 6 4
- Transporter 4
- Sodium-dependent serotonin transporter 3
- Alpha-1A/Alpha-2A adrenergic receptor 3
- Alpha-2C adrenergic receptor 3
- Histamine H1 receptor 3
- Serotonin 2 (5-HT2) receptor 3
- Alpha-2A adrenergic receptor 3
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 2
- D(4) dopamine receptor 2
- Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor 2
- Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor 2
- 5-hydroxytryptamine receptor 2B 2
- Sodium-dependent dopamine transporter 2
- 5-hydroxytryptamine receptor 1D 2
- Histamine H2 receptor 2
- Sphingosine 1-phosphate receptor 3 1
- 5-hydroxytryptamine receptor 3A/3B 1
- 5-hydroxytryptamine receptor 1B 1
- Muscarinic acetylcholine receptor M5 1
- D(1A) dopamine receptor 1
- 5-hydroxytryptamine receptor 1E 1
- Alpha-1A adrenergic receptor/Alpha-1B adrenergic receptor/Alpha-1D adrenergic receptor/Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor 1
- ...
Publications 27 ▿
- Bioorg Med Chem Lett 12: 243-8 (2001) 13
- J Med Chem 48: 1709-12 (2005) 10
- Bioorg Med Chem Lett 12: 249-53 (2001) 9
- J Med Chem 30: 1433-54 (1987) 8
- J Med Chem 45: 3280-5 (2002) 7
- J Med Chem 30: 1-12 (1987) 5
- J Med Chem 26: 1116-22 (1983) 5
- J Med Chem 56: 1211-27 (2013) 4
- J Med Chem 46: 2795-812 (2003) 3
- J Med Chem 27: 943-6 (1984) 3
- Naunyn Schmiedebergs Arch Pharmacol 370: 114-23 (2004) 3
- J Med Chem 42: 3154-62 (1999) 3
- Mol Pharmacol 64: 1295-308 (2003) 3
- J Med Chem 27: 495-503 (1984) 2
- J Med Chem 26: 1696-701 (1984) 2
- J Med Chem 40: 952-60 (1997) 1
- J Med Chem 36: 1499-500 (1993) 1
- J Med Chem 27: 1182-5 (1984) 1
- J Pharmacol Exp Ther 308: 481-6 (2004) 1
- PubChem Bioassay (2007) 1
- Eur J Med Chem 46: 4474-88 (2011) 1
- PubChem Bioassay (2007) 1
- Bioorg Med Chem Lett 10: 1097-100 (2000) 1
- Medicinal Chemistry Research 17: 507-514 (2008) 1
- PubChem Bioassay (2007) 1
- J Med Chem 46: 265-83 (2003) 1
- J Med Chem 27: 995-1003 (1984) 1
Institutions 17 ▿
- [TBA] 27
- [Janssen-Cilag] 22
- [Johnson & Johnson Pharmaceutical Research & Development] 10
- [University Center for Pharmacy] 7
- [University of Copenhagen] 4
- [GlaxoSmithKline, Vernalis Research, Virginia Commonwealth University, Universidad de Valencia, The Scripps Research Institute Molecular Screening Center] 3
- [GlaxoSmithKline, Vernalis Research, Virginia Commonwealth University, Universidad de Valencia, The Scripps Research Institute Molecular Screening Center] 3
- [GlaxoSmithKline, Vernalis Research, Virginia Commonwealth University, Universidad de Valencia, The Scripps Research Institute Molecular Screening Center] 3
- [GlaxoSmithKline, Vernalis Research, Virginia Commonwealth University, Universidad de Valencia, The Scripps Research Institute Molecular Screening Center] 3
- [GlaxoSmithKline, Vernalis Research, Virginia Commonwealth University, Universidad de Valencia, The Scripps Research Institute Molecular Screening Center] 3
- [H. Lundbeck A/S, Medical University of Warsaw, University of Pennsylvania, National Institutes of Health, Cooperation Pharmaceutique Fran�aise, Universidad Complutense, The Medical University of Warsaw] 1
- [H. Lundbeck A/S, Medical University of Warsaw, University of Pennsylvania, National Institutes of Health, Cooperation Pharmaceutique Fran�aise, Universidad Complutense, The Medical University of Warsaw] 1
- [H. Lundbeck A/S, Medical University of Warsaw, University of Pennsylvania, National Institutes of Health, Cooperation Pharmaceutique Fran�aise, Universidad Complutense, The Medical University of Warsaw] 1
- [H. Lundbeck A/S, Medical University of Warsaw, University of Pennsylvania, National Institutes of Health, Cooperation Pharmaceutique Fran�aise, Universidad Complutense, The Medical University of Warsaw] 1
- [H. Lundbeck A/S, Medical University of Warsaw, University of Pennsylvania, National Institutes of Health, Cooperation Pharmaceutique Fran�aise, Universidad Complutense, The Medical University of Warsaw] 1
- [H. Lundbeck A/S, Medical University of Warsaw, University of Pennsylvania, National Institutes of Health, Cooperation Pharmaceutique Fran�aise, Universidad Complutense, The Medical University of Warsaw] 1
- [H. Lundbeck A/S, Medical University of Warsaw, University of Pennsylvania, National Institutes of Health, Cooperation Pharmaceutique Fran�aise, Universidad Complutense, The Medical University of Warsaw] 1
Affinity: 0.0060 to 5.0E+4 nM▿
- Ki 54
- IC50 35
- EC50 3
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1