BindingDB

null

SMILES CN1CCN(CC1)C1=Nc2ccccc2Oc2ccc(Cl)cc12

InChI Key InChIKey=XJGVXQDUIWGIRW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 22871

Bile salt export pump(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL

BDBM22871(13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azat...)copy SMILEScopy InChI

IC50: 7.70E+4nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair

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Details Article
BindingDB Entry DOI: 10.7270/Q2JM2D2DPubMed

Targets 27 ▿
- D(2) dopamine receptor 19
- D(4) dopamine receptor 10
- 5-hydroxytryptamine receptor 6 9
- 5-hydroxytryptamine receptor 2A 8
- 5-hydroxytryptamine receptor 2C 7
- 5-hydroxytryptamine receptor 7 6
- Histamine H1 receptor 4
- Alpha-1A adrenergic receptor 3
- Muscarinic acetylcholine receptor M2 3
- Alpha-2A adrenergic receptor 3
- D(3) dopamine receptor 2
- Potassium channel subfamily K member 2 2
- Muscarinic acetylcholine receptor M3 2
- Muscarinic acetylcholine receptor M1 2
- Alpha-2B adrenergic receptor 1
- Muscarinic acetylcholine receptor M5 1
- Muscarinic acetylcholine receptor M4 1
- Histamine H4 receptor 1
- ATP-binding cassette sub-family C member 3 1
- ATP-binding cassette sub-family C member 4 1
- Alpha-2C adrenergic receptor 1
- ATP-binding cassette sub-family C member 2 1
- 5-hydroxytryptamine receptor 1A 1
- D(1A) dopamine receptor 1
- 5-hydroxytryptamine receptor 1A/1B/1D/2C 1
- Bile salt export pump 1
- Neutrophil cytosol factor 1 [S99G] 1
- ...
Publications 29 ▿
- Neuropsychopharmacology 28: 519-26 (2003) 12
- Eur J Pharmacol 291: 59-66 (1995) 8
- Ann N Y Acad Sci 537: 435-42 (1988) 7
- J Med Chem 42: 2235-44 (1999) 7
- J Pharmacol Exp Ther 260: 576-80 (1992) 5
- J Pharmacol Exp Ther 268: 1403-10 (1994) 5
- Eur J Pharmacol 103: 197-204 (1984) 5
- Toxicol Sci 136: 216-41 (2013) 4
- Mol Psychiatry 3: 123-34 (1998) 4
- Psychopharmacology (Berl) 120: 365-8 (1995) 3
- Neuropharmacology 33: 275-317 (1994) 3
- Neuropsychopharmacology 16: 93 (1997) 3
- J Med Chem 46: 2795-812 (2003) 2
- Br J Pharmacol 130: 692-8 (2000) 2
- J Med Chem 37: 2686-96 (1994) 2
- Eur J Pharmacol 236: 483-6 (1993) 2
- Eur J Pharmacol 146: 113-20 (1988) 2
- J Pharmacol Exp Ther 260: 1361-5 (1992) 2
- J Med Chem 38: 708-14 (1995) 2
- J Biol Chem 268: 18200-4 (1993) 2
- J Med Chem 55: 1572-82 (2012) 2
- Mol Pharmacol 43: 320-7 (1993) 2
- J Pharmacol Exp Ther 295: 226-32 (2000) 1
- J Med Chem 47: 143-57 (2003) 1
- J Pharmacol Exp Ther 314: 1310-21 (2005) 1
- Chem Biol Drug Des 88: 807-819 (2016) 1
- PubChem Bioassay (2008) 1
- J Neurochem 66: 47-56 (1996) 1
- J Med Chem 59: 5149-57 (2016) 1
Institutions 22 ▿
- [Case Western Reserve University] 20
- [University of Toronto] 15
- [Mayo Clinic and Foundation] 12
- [University of Göteborg] 7
- [Mayo Clinic Jacksonville] 5
- [National Institute of Neurological Disorders and Stroke, Amgen Inc, Vanderbilt University] 4
- [National Institute of Neurological Disorders and Stroke, Amgen Inc, Vanderbilt University] 4
- [National Institute of Neurological Disorders and Stroke, Amgen Inc, Vanderbilt University] 4
- [University of Alberta] 3
- [Friedrich-Schiller-University Jena, NOVO Industri A/S, Maryland Psychiatric Research Center, Virginia Commonwealth University, University of Li£ge , Stanford University ] 2
- [Friedrich-Schiller-University Jena, NOVO Industri A/S, Maryland Psychiatric Research Center, Virginia Commonwealth University, University of Li£ge , Stanford University ] 2
- [Friedrich-Schiller-University Jena, NOVO Industri A/S, Maryland Psychiatric Research Center, Virginia Commonwealth University, University of Li£ge , Stanford University ] 2
- [Friedrich-Schiller-University Jena, NOVO Industri A/S, Maryland Psychiatric Research Center, Virginia Commonwealth University, University of Li£ge , Stanford University ] 2
- [Friedrich-Schiller-University Jena, NOVO Industri A/S, Maryland Psychiatric Research Center, Virginia Commonwealth University, University of Li£ge , Stanford University ] 2
- [Friedrich-Schiller-University Jena, NOVO Industri A/S, Maryland Psychiatric Research Center, Virginia Commonwealth University, University of Li£ge , Stanford University ] 2
- [Emory University Molecular Libraries Screening Center, Universit£ degli Studi di Siena, Albany Medical College, University of Washington, Korea Institute of Science and Technology, Vrije Universiteit Amsterdam, Universit£ Clermont Auvergne] 1
- [Emory University Molecular Libraries Screening Center, Universit£ degli Studi di Siena, Albany Medical College, University of Washington, Korea Institute of Science and Technology, Vrije Universiteit Amsterdam, Universit£ Clermont Auvergne] 1
- [Emory University Molecular Libraries Screening Center, Universit£ degli Studi di Siena, Albany Medical College, University of Washington, Korea Institute of Science and Technology, Vrije Universiteit Amsterdam, Universit£ Clermont Auvergne] 1
- [Emory University Molecular Libraries Screening Center, Universit£ degli Studi di Siena, Albany Medical College, University of Washington, Korea Institute of Science and Technology, Vrije Universiteit Amsterdam, Universit£ Clermont Auvergne] 1
- [Emory University Molecular Libraries Screening Center, Universit£ degli Studi di Siena, Albany Medical College, University of Washington, Korea Institute of Science and Technology, Vrije Universiteit Amsterdam, Universit£ Clermont Auvergne] 1
- [Emory University Molecular Libraries Screening Center, Universit£ degli Studi di Siena, Albany Medical College, University of Washington, Korea Institute of Science and Technology, Vrije Universiteit Amsterdam, Universit£ Clermont Auvergne] 1
- [Emory University Molecular Libraries Screening Center, Universit£ degli Studi di Siena, Albany Medical College, University of Washington, Korea Institute of Science and Technology, Vrije Universiteit Amsterdam, Universit£ Clermont Auvergne] 1
Affinity: 1.7 to 1.3E+5 nM▿
- Ki 79
- IC50 13
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1