null

SMILES Cc1cc(\N=N\c2ccc(cc2)S(=O)(=O)NC2CCCC2)c(N)cc1O

InChI Key InChIKey=IRKMSULWLDLTIK-QZQOTICOSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50370181   

TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)copy SMILEScopy InChI
Affinity DataIC50: 810nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG54 RNA expression preincubated for 24 hrs followed ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X069KMPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)copy SMILEScopy InChI
Affinity DataIC50: 790nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced grobeta RNA expression preincubated for 24 hrs followe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X069KMPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibition of BRD4 BD1 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X069KMPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)copy SMILEScopy InChI
Affinity DataIC50: 860nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced ISG56 RNA expression preincubated for 24 hrs followed ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X069KMPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)copy SMILEScopy InChI
Affinity DataIC50: 730nMAssay Description:Inhibition of BRD4 in human SAE cells assessed as reduction in TLR3 agonist poly(I:C) -induced IL-8 RNA expression preincubated for 24 hrs followed b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X069KMPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50370181(CHEMBL4159382 | US11117865, Compound ZL0454)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of BRD4 BD2 (unknown origin) after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X069KMPubMed