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SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccccc23)[nH]1

InChI Key InChIKey=WUWDLXZGHZSWQZ-WQLSENKSSA-N

PDB links: 1 PDB ID matches this monomer. 3 PDB IDs contain this monomer as substructures. 3 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 4810   

TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
SUGEN, Inc.

LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)copy SMILEScopy InChI
Affinity DataIC50: 7.08E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20Z71GMPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
SUGEN, Inc.

LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)copy SMILEScopy InChI
Affinity DataIC50: 7.08E+3nMAssay Description:The assays were performed in 96-well microtiter plates that had been coated with a polyGluTyr peptide. Negative control wells received buffer alone w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W66J0NPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
SUGEN, Inc.

LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+3nMAssay Description:In vitro inhibition of Fibroblast growth factor receptor 1 expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZK5HDNPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
SUGEN, Inc.

LigandPNGBDBM4810((3Z)-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:In vitro inhibition of Fibroblast growth factor receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2ZK5HDNPubMed