BindingDB

null

SMILES CO[C@H]1C[C@H](C)CC2=C(OC)C(=O)C=C(NC(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@H]1O)C2=O

InChI Key InChIKey=QTQAWLPCGQOSGP-KSRBKZBZSA-N

PDB links: 10 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50008059

Heat shock protein HSP 90(Oryctolagus cuniculus)
Tufts University

Curated by ChEMBL

BDBM50008059(CHEBI:5292 | GELDANAMYCIN)copy SMILEScopy InChI

IC50: 282nMAssay Description:Inhibition of HSP90 in rabbit reticulocyte lysate after 90 mins by luciferase renaturation assayMore data for this Ligand-Target Pair

UniProtKB/SwissProt
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Details Article
BindingDB Entry DOI: 10.7270/Q24F1SDMPubMed

Targets 11 ▿
- Heat shock protein HSP 90-alpha 19
- Heat shock protein HSP 90-alpha/90-beta 5
- Breakpoint cluster region protein/Tyrosine-protein kinase ABL1 4
- Heat shock protein HSP 90-beta 3
- Heat shock protein 90, putative 1
- Putative heat shock protein HSP 90-alpha A4 1
- Lysine-specific demethylase 5A 1
- Lysine-specific demethylase 6B 1
- Lysine-specific demethylase 4C 1
- Heat shock protein HSP 90 1
- Lysine-specific demethylase 4B 1
Publications 15 ▿
- Bioorg Med Chem Lett 26: 4287-91 (2016) 10
- J Med Chem 59: 5563-86 (2016) 6
- J Med Chem 57: 2524-35 (2014) 2
- Bioorg Med Chem 22: 3989-93 (2014) 2
- J Med Chem 59: 6344-52 (2016) 2
- Bioorg Med Chem Lett 28: 1357-1362 (2018) 2
- Chem Biol Drug Des 85: 181-8 (2015) 1
- Bioorg Med Chem Lett 30: (2020) 1
- Eur J Med Chem 87: 346-63 (2014) 1
- Eur J Med Chem 143: 390-401 (2018) 1
- J Med Chem 62: 10005-10025 (2019) 1
- Bioorg Med Chem Lett 24: 2525-9 (2014) 1
- Eur J Med Chem 85: 359-70 (2014) 1
- Eur J Med Chem 124: 1069-1080 (2016) 1
- Bioorg Med Chem Lett 9: 1233-8 (1999) 1
Institutions 12 ▿
- [Peking Union Medical College & Chinese Academy of Medical Sciences] 10
- [Chinese Academy of Sciences ] 6
- [Shandong University] 3
- [National University of Singapore, Keimyung University, University of Geneva, Universit£ de Gen£ve, Tufts University] 2
- [National University of Singapore, Keimyung University, University of Geneva, Universit£ de Gen£ve, Tufts University] 2
- [National University of Singapore, Keimyung University, University of Geneva, Universit£ de Gen£ve, Tufts University] 2
- [National University of Singapore, Keimyung University, University of Geneva, Universit£ de Gen£ve, Tufts University] 2
- [National University of Singapore, Keimyung University, University of Geneva, Universit£ de Gen£ve, Tufts University] 2
- [South China Sea Institute of Oceanology, Sloan-Kettering Institute for Cancer Research, Boston University, Chinese Academy of Sciences] 1
- [South China Sea Institute of Oceanology, Sloan-Kettering Institute for Cancer Research, Boston University, Chinese Academy of Sciences] 1
- [South China Sea Institute of Oceanology, Sloan-Kettering Institute for Cancer Research, Boston University, Chinese Academy of Sciences] 1
- [South China Sea Institute of Oceanology, Sloan-Kettering Institute for Cancer Research, Boston University, Chinese Academy of Sciences] 1
Affinity: 10 to 5.0E+3 nM▿
- IC50 33
- Kd 5
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1