BindingDB

null

SMILES Cn1c(Nc2ccc(cc2)C(F)(F)F)nc2cc(Oc3ccnc(c3)-c3ncc([nH]3)C(F)(F)F)ccc12

InChI Key InChIKey=YABJJWZLRMPFSI-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 31088

Mitogen-activated protein kinase kinase kinase 1(Homo sapiens (Human))
Ambit Biosciences

Curated by ChEMBL

BDBM31088(1-methyl-5-[2-[5-(trifluoromethyl)-1H-imidazol-2-y...)copy SMILEScopy InChI

Kd: >1.00E+4nMAssay Description:Binding constant for MAP3K1 kinase domainMore data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
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Details Article
BindingDB Entry DOI: 10.7270/Q25D8S70PubMed

Targets 387 ▿
- Tyrosine-protein kinase ABL1 27
- Epidermal growth factor receptor 22
- Mast/stem cell growth factor receptor Kit 20
- Receptor-type tyrosine-protein kinase FLT3 13
- Serine/threonine-protein kinase B-raf 13
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 12
- Proto-oncogene tyrosine-protein kinase receptor Ret 6
- RAF proto-oncogene serine/threonine-protein kinase 5
- Tyrosine-protein kinase Lck 4
- Ephrin type-A receptor 6 4
- Tyrosine-protein kinase Fyn 4
- Ribosomal protein S6 kinase alpha-6 4
- Ribosomal protein S6 kinase alpha-4 4
- Ribosomal protein S6 kinase alpha-5 4
- Ribosomal protein S6 kinase alpha-2 4
- Ribosomal protein S6 kinase alpha-1 4
- Hepatocyte growth factor receptor 4
- Platelet-derived growth factor receptor beta 4
- Proto-oncogene tyrosine-protein kinase Src 4
- Mitogen-activated protein kinase 14 4
- Vascular endothelial growth factor receptor 2 4
- Fibroblast growth factor receptor 3 4
- Ephrin type-A receptor 2 3
- Tyrosine-protein kinase receptor Tie-1 3
- Death-associated protein kinase 3 3
- Tyrosine-protein kinase JAK1 3
- Receptor-interacting serine/threonine-protein kinase 2 3
- Tyrosine-protein kinase FRK 3
- Angiopoietin-1 receptor 3
- Serine/threonine-protein kinase TNNI3K 3
- Interferon-induced, double-stranded RNA-activated protein kinase 3
- Cyclin-dependent kinase 19 3
- STE20-like serine/threonine-protein kinase 3
- Protein-tyrosine kinase 6 3
- Mitogen-activated protein kinase kinase kinase kinase 4 3
- Mitogen-activated protein kinase kinase kinase kinase 5 3
- Non-receptor tyrosine-protein kinase TYK2 3
- 5'-AMP-activated protein kinase catalytic subunit alpha-1 3
- Tyrosine-protein kinase HCK 3
- Mitogen-activated protein kinase kinase kinase 20 3
- Fibroblast growth factor receptor 1 3
- Vascular endothelial growth factor receptor 3 3
- Vascular endothelial growth factor receptor 1 3
- Serine/threonine-protein kinase Nek5 3
- Tyrosine-protein kinase ABL2 3
- Citron Rho-interacting kinase 3
- Macrophage colony-stimulating factor 1 receptor 3
- Tyrosine-protein kinase Lyn 3
- eIF-2-alpha kinase GCN2 3
- Platelet-derived growth factor receptor alpha 3
- TRAF2 and NCK-interacting protein kinase 3
- Ephrin type-A receptor 8 3
- Epithelial discoidin domain-containing receptor 1 3
- Myosin light chain kinase, smooth muscle 3
- Tyrosine-protein kinase Tec 2
- BMP-2-inducible protein kinase 2
- Cyclin-dependent kinase 11B 2
- Cyclin-dependent kinase 11A 2
- LIM domain kinase 1 2
- LIM domain kinase 2 2
- ALK tyrosine kinase receptor 2
- NUAK family SNF1-like kinase 2 2
- Glycogen synthase kinase-3 beta 2
- Calcium/calmodulin-dependent protein kinase type 1 2
- NUAK family SNF1-like kinase 1 2
- Calcium/calmodulin-dependent protein kinase type II subunit beta 2
- AP2-associated protein kinase 1 2
- Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2
- Serine/threonine-protein kinase PAK 1 2
- Protein kinase C theta type 2
- Serine/threonine-protein kinase PAK 2 2
- Serine/threonine-protein kinase PAK 3 2
- Dual specificity mitogen-activated protein kinase kinase 2 2
- Serine/threonine-protein kinase PAK 4 2
- Phosphatidylinositol 5-phosphate 4-kinase type-2 beta 2
- Serine/threonine-protein kinase tousled-like 2 2
- Dual specificity mitogen-activated protein kinase kinase 3 2
- Serine/threonine-protein kinase PAK 5 2
- Serine/threonine-protein kinase PAK 6 2
- Serine/threonine-protein kinase tousled-like 1 2
- Tyrosine-protein kinase JAK3 2
- Tyrosine-protein kinase JAK2 2
- Dual specificity mitogen-activated protein kinase kinase 1 2
- Dual specificity mitogen-activated protein kinase kinase 6 2
- Dual specificity mitogen-activated protein kinase kinase 4 2
- Leucine-rich repeat serine/threonine-protein kinase 2 2
- Tyrosine-protein kinase ZAP-70 2
- Casein kinase I isoform gamma-3 2
- Casein kinase I isoform gamma-2 2
- Casein kinase I isoform epsilon 2
- Casein kinase I isoform gamma-1 2
- Ephrin type-A receptor 1 2
- Ephrin type-A receptor 3 2
- Ephrin type-A receptor 5 2
- Tyrosine-protein kinase BTK 2
- Ephrin type-A receptor 4 2
- Tyrosine-protein kinase receptor UFO 2
- Insulin-like growth factor 1 receptor 2
- Activin receptor type-1 2
- Myosin light chain kinase 2, skeletal/cardiac muscle 2
- Tyrosine-protein kinase Srms 2
- Wee1-like protein kinase 2
- Ankyrin repeat and protein kinase domain-containing protein 1 2
- Focal adhesion kinase 1 2
- Cyclin-dependent kinase 2 2
- Tyrosine-protein kinase TXK 2
- Death-associated protein kinase 2 2
- Death-associated protein kinase 1 2
- Serine/threonine-protein kinase D2 2
- Serine/threonine-protein kinase D3 2
- TGF-beta receptor type-2 2
- Serine/threonine-protein kinase D1 2
- Dual specificity tyrosine-phosphorylation-regulated kinase 1B 2
- Cyclin-dependent kinase 9 2
- Cyclin-dependent kinase 8 2
- Serine/threonine-protein kinase pim-3 2
- Cyclin-dependent kinase 7 2
- Serine/threonine-protein kinase pim-1 2
- Cyclin-dependent kinase 5 2
- Serine/threonine-protein kinase pim-2 2
- Cyclin-dependent kinase 4 2
- Cyclin-dependent kinase 3 2
- Serine/threonine-protein kinase 36 2
- Testis-specific serine/threonine-protein kinase 1 2
- Cyclin-dependent kinase 16 2
- Protein kinase C epsilon type 2
- Cyclin-dependent kinase 17 2
- Bone morphogenetic protein receptor type-2 2
- Casein kinase II subunit alpha 2
- Cyclin-dependent kinase 14 2
- Leukocyte tyrosine kinase receptor 2
- Cytoplasmic tyrosine-protein kinase BMX 2
- Atypical kinase COQ8B, mitochondrial 2
- Calcium/calmodulin-dependent protein kinase type II subunit alpha 2
- cGMP-dependent protein kinase 2 2
- cGMP-dependent protein kinase 1 2
- Serine/threonine-protein kinase SIK2 2
- Tyrosine-protein kinase Fes/Fps 2
- Serine/threonine-protein kinase SIK1 2
- 3-phosphoinositide-dependent protein kinase 1 2
- Mitogen-activated protein kinase 1 2
- Serine/threonine-protein kinase 3 2
- Discoidin domain-containing receptor 2 2
- Mitogen-activated protein kinase 3 2
- Mitogen-activated protein kinase 4 2
- Serine/threonine-protein kinase 4 2
- Mitogen-activated protein kinase 9 2
- SRSF protein kinase 2 2
- Mitogen-activated protein kinase 6 2
- Mitogen-activated protein kinase 7 2
- Mitogen-activated protein kinase 8 2
- Calcium/calmodulin-dependent protein kinase type IV 2
- Tyrosine-protein kinase SYK 2
- Serine/threonine-protein kinase RIO1 2
- Serine/threonine-protein kinase LATS1 2
- Serine/threonine-protein kinase RIO3 2
- Serine/threonine-protein kinase 32B 2
- Serine/threonine-protein kinase 32C 2
- Insulin receptor 2
- Serine/threonine-protein kinase PLK1 2
- Insulin receptor-related protein 2
- Serine/threonine-protein kinase PLK3 2
- Serine/threonine-protein kinase PLK4 2
- Tyrosine-protein kinase receptor TYRO3 2
- Serine/threonine-protein kinase BRSK1 2
- Serine/threonine-protein kinase LATS2 2
- cAMP-dependent protein kinase catalytic subunit alpha 2
- Serine/threonine-protein kinase BRSK2 2
- Serine/threonine-protein kinase Chk1 2
- cAMP-dependent protein kinase catalytic subunit PRKX 2
- SRSF protein kinase 1 2
- Tyrosine-protein kinase Yes 2
- Serine/threonine-protein kinase MRCK beta 2
- Serine/threonine-protein kinase MRCK gamma 2
- Casein kinase II subunit alpha' 2
- Serine/threonine-protein kinase STK11 2
- Cyclin-G-associated kinase 2
- Receptor tyrosine-protein kinase erbB-2 2
- Serine/threonine-protein kinase Nek9 2
- Serine/threonine-protein kinase Nek7 2
- Glycogen synthase kinase-3 alpha 2
- Serine/threonine-protein kinase Nek6 2
- Serine/threonine-protein kinase Nek2 2
- Serine/threonine-protein kinase Nek1 2
- Serine/threonine-protein kinase receptor R3 2
- MAP/microtubule affinity-regulating kinase 3 2
- MAP kinase-interacting serine/threonine-protein kinase 2 2
- MAP kinase-interacting serine/threonine-protein kinase 1 2
- Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase 2
- MAP/microtubule affinity-regulating kinase 4 2
- Serine/threonine-protein kinase 10 2
- Serine/threonine-protein kinase 38-like 2
- Dual specificity protein kinase TTK 2
- Myosin-IIIb 2
- Myosin-IIIa 2
- Tyrosine-protein kinase ITK/TSK 2
- Myotonin-protein kinase 2
- Protein kinase C eta type 2
- Bone morphogenetic protein receptor type-1A 2
- Receptor-interacting serine/threonine-protein kinase 1 2
- Tyrosine-protein kinase Blk 2
- Serine/threonine-protein kinase 16 2
- Non-receptor tyrosine-protein kinase TNK1 2
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 2
- Serine/threonine-protein kinase NLK 2
- Casein kinase I isoform delta 2
- Cyclin-dependent kinase 18 [3-474] 2
- Serine/threonine-protein kinase 26 2
- Serine/threonine-protein kinase 24 2
- Dual specificity testis-specific protein kinase 1 2
- Serine/threonine-protein kinase 25 2
- Ephrin type-B receptor 3 2
- Serine/threonine-protein kinase 33 2
- Ephrin type-B receptor 4 2
- Ephrin type-B receptor 1 2
- Proto-oncogene tyrosine-protein kinase receptor Ret [1-999,M918T] 2
- Ephrin type-B receptor 2 2
- Activated CDC42 kinase 1 2
- MAP kinase-activated protein kinase 2 2
- MAP kinase-activated protein kinase 5 2
- Heat shock factor protein 1 2
- Muscle, skeletal receptor tyrosine-protein kinase 2
- Tyrosine-protein kinase Fer 2
- 5'-AMP-activated protein kinase catalytic subunit alpha-2 2
- Calcium/calmodulin-dependent protein kinase type II subunit delta 2
- Proto-oncogene tyrosine-protein kinase ROS 2
- Calcium/calmodulin-dependent protein kinase kinase 1 2
- Serine/threonine-protein kinase DCLK1 2
- Calcium/calmodulin-dependent protein kinase kinase 2 2
- Serine/threonine-protein kinase DCLK2 2
- Serine/threonine-protein kinase DCLK3 2
- Mitogen-activated protein kinase kinase kinase kinase 3 2
- Mitogen-activated protein kinase kinase kinase kinase 1 2
- Serine/threonine-protein kinase MRCK alpha 2
- Casein kinase I isoform alpha-like 2
- Mitogen-activated protein kinase 15 2
- Activin receptor type-1B 2
- Myosin light chain kinase family member 4 2
- Mitogen-activated protein kinase kinase kinase 9 2
- RAC-gamma serine/threonine-protein kinase 2
- Mitogen-activated protein kinase kinase kinase 5 2
- Interleukin-1 receptor-associated kinase 3 2
- Mitogen-activated protein kinase kinase kinase 4 2
- RAC-alpha serine/threonine-protein kinase 2
- Activin receptor type-2B 2
- Activin receptor type-2A 2
- BDNF/NT-3 growth factors receptor 2
- Serine/threonine-protein kinase 17A 2
- Serine/threonine-protein kinase 17B 2
- Dual specificity protein kinase CLK1 2
- Protein kinase C delta type 2
- NT-3 growth factor receptor 2
- Dual specificity protein kinase CLK4 2
- Dual specificity protein kinase CLK3 2
- Dual specificity protein kinase CLK2 2
- Protein-tyrosine kinase 2-beta 2
- High affinity nerve growth factor receptor 2
- Tyrosine-protein kinase Mer 2
- Serine/threonine-protein kinase N2 2
- Calcium/calmodulin-dependent protein kinase type II subunit gamma 2
- cAMP-dependent protein kinase catalytic subunit beta 2
- Serine/threonine-protein kinase N1 2
- Ribosomal protein S6 kinase alpha-3 2
- Calcium/calmodulin-dependent protein kinase type 1D 2
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 2
- Calcium/calmodulin-dependent protein kinase type 1G 2
- Fibroblast growth factor receptor 4 2
- Tyrosine-protein kinase Fgr 2
- Aurora kinase B 2
- Aurora kinase A 2
- Fibroblast growth factor receptor 2 2
- Atypical kinase COQ8A, mitochondrial 2
- Aurora kinase C 2
- Mitogen-activated protein kinase 12 2
- Mitogen-activated protein kinase 11 2
- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha 2
- RAC-beta serine/threonine-protein kinase 2
- Mitogen-activated protein kinase 10 2
- Tyrosine-protein kinase CSK 2
- Maternal embryonic leucine zipper kinase 2
- Serine/threonine-protein kinase MARK1 2
- Serine/threonine-protein kinase MARK2 2
- Mitogen-activated protein kinase kinase kinase 10 2
- Mitogen-activated protein kinase kinase kinase 11 2
- Peripheral plasma membrane protein CASK 1
- Tubulin alpha-1A chain 1
- Receptor tyrosine-protein kinase erbB-4 1
- Rhodopsin kinase GRK1 1
- Uncharacterized serine/threonine-protein kinase SBK3 1
- Receptor tyrosine-protein kinase erbB-3 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
- Discoidin domain-containing receptor 2 [A642S] 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Protein kinase C iota type 1
- Transient receptor potential cation channel subfamily M member 6 1
- Serine/threonine-protein kinase Nek4 1
- Serine/threonine-protein kinase Nek3 1
- Macrophage-stimulating protein receptor 1
- Cyclin-dependent kinase-like 3 1
- Cyclin-dependent kinase-like 2 1
- Serine/threonine-protein kinase SIK3 [59-1321] 1
- Homeodomain-interacting protein kinase 4 1
- Homeodomain-interacting protein kinase 3 1
- Cyclin-dependent kinase-like 5 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Dual specificity mitogen-activated protein kinase kinase 5 1
- Serine/threonine-protein kinase Sgk3 1
- Myosin light chain kinase 3 1
- Serine/threonine-protein kinase Nek11 1
- Serine/threonine-protein kinase mTOR 1
- Eukaryotic translation initiation factor 2-alpha kinase 1 1
- Ephrin type-A receptor 7 1
- Bone morphogenetic protein receptor type-1B 1
- SNF-related serine/threonine-protein kinase 1
- Homeodomain-interacting protein kinase 2 1
- Homeodomain-interacting protein kinase 1 1
- Receptor-interacting serine/threonine-protein kinase 4 1
- Ribosomal protein S6 kinase beta-1 1
- Serine/threonine-protein kinase OSR1 1
- Serine/threonine-protein kinase MAK 1
- Serine/threonine-protein kinase/endoribonuclease IRE1 1
- Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma 1
- Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma 1
- Serine/threonine-protein kinase SBK1 1
- Ephrin type-B receptor 6 1
- Rhodopsin kinase GRK7 1
- Vascular endothelial growth factor receptor 1/2/3 1
- STE20/SPS1-related proline-alanine-rich protein kinase 1
- Tyrosine-protein kinase ABL1 [1-999,Q252H] 1
- Phosphatidylinositol 4-kinase beta 1
- Calcium-dependent protein kinase 1 1
- Dual serine/threonine and tyrosine protein kinase 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma 1
- Serine/threonine-protein kinase TAO1 1
- Serine/threonine-protein kinase PknB 1
- Serine/threonine-protein kinase 38 1
- Serine/threonine-protein kinase TAO3 1
- Serine/threonine-protein kinase 35 1
- Serine/threonine-protein kinase PRP4 homolog 1
- Serine/threonine-protein kinase TAO2 1
- Mitogen-activated protein kinase kinase kinase kinase 2 1
- Cyclin-dependent kinase-like 1 [2-358] 1
- Cyclin-dependent kinase 2 homolog 1
- Cyclin-dependent kinase 13 1
- Cyclin-dependent kinase 15 1
- Interleukin-1 receptor-associated kinase 4 1
- Serine/threonine-protein kinase VRK2 1
- Mitogen-activated protein kinase kinase kinase 6 1
- Interleukin-1 receptor-associated kinase 1 1
- Mitogen-activated protein kinase kinase kinase 7 1
- Mitogen-activated protein kinase kinase kinase 2 1
- Tyrosine-protein kinase ABL1 [T315I] 1
- Mitogen-activated protein kinase kinase kinase 1 1
- Mitogen-activated protein kinase kinase kinase 3 1
- Serine/threonine-protein kinase ICK 1
- Microtubule-associated serine/threonine-protein kinase 1 1
- Megakaryocyte-associated tyrosine-protein kinase 1
- Rho-associated protein kinase 2 1
- Rho-associated protein kinase 1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Serine/threonine-protein kinase ULK1 1
- Serine/threonine-protein kinase ULK2 1
- Serine/threonine-protein kinase ULK3 1
- Mitogen-activated protein kinase kinase kinase 19 1
- Pirin 1
- Mitogen-activated protein kinase kinase kinase 15 1
- SRSF protein kinase 3 1
- G protein-coupled receptor kinase 4 1
- Serine/threonine-protein kinase TBK1 1
- Hormonally up-regulated neu tumor-associated kinase 1
- Serine/threonine-protein kinase RIO2 1
- Serine/threonine-protein kinase 32A 1
- Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta 1
- Cytochrome P450 3A4 1
- Serine/threonine-protein kinase PLK2 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Serine/threonine-protein kinase NIM1 1
- Mitogen-activated protein kinase 13 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Wee1-like protein kinase 2 1
- Casein kinase I isoform alpha 1
- Misshapen-like kinase 1 1
- Serine/threonine-protein kinase Chk2 1
- Mitogen-activated protein kinase kinase kinase 12 1
- Mitogen-activated protein kinase kinase kinase 13 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 2 1
- ...
Publications 46 ▿
- Nat Biotechnol 29: 1046-51 (2011) 442
- Nat Biotechnol 26: 127-32 (2008) 317
- PubChem Bioassay (2008) 15
- ACS Med Chem Lett 6: 961-5 (2015) 14
- ACS Med Chem Lett 9: 1199-1204 (2018) 2
- J Med Chem 60: 180-201 (2017) 2
- Bioorg Med Chem 19: 3312-9 (2011) 2
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- Eur J Med Chem 46: 2043-57 (2011) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
- PubChem Bioassay (2008) 1
Institutions 6 ▿
- [Ambit Biosciences] 812
- [Novartis Institutes for Biomedical Research] 14
- [Tsinghua University, The Institute of Cancer Research, The Institute of Cancer Research ] 2
- [Tsinghua University, The Institute of Cancer Research, The Institute of Cancer Research ] 2
- [Tsinghua University, The Institute of Cancer Research, The Institute of Cancer Research ] 2
- [University of the Pacific] 1
Affinity: 0.5 to 6.2E+6 nM▿
- Ki 6
- IC50 20
- Kd 807
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1