BindingDB

null

SMILES NC12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=DKNWSYNQZKUICI-UHFFFAOYSA-N

PDB links: 8 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50033369

Multidrug and toxin extrusion protein 1(Homo sapiens (Human))
University of California

Curated by ChEMBL

BDBM50033369(AMANTADINE | CHEMBL660 | SYMADINE | SYMMETREL)copy SMILEScopy InChI

IC50: 3.78E+4nMAssay Description:Inhibition of human MATE1-mediated ASP+ uptake expressed in HEK293 cells after 1.5 mins by fluorescence assayMore data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

Purchase CHEMBL DrugBank MCE
KEGG MMDB PC cid PC sid PDB Patents Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2F76DWZPubMed

Targets 8 ▿
- Matrix protein 2 11
- Glutamate receptor ionotropic, NMDA 1 7
- Solute carrier family 22 member 2 5
- Solute carrier family 22 member 1 4
- Glutamate receptor ionotropic, NMDA 1/2A 2
- Matrix protein 2 [1-96] 2
- Sigma non-opioid intracellular receptor 1 1
- Multidrug and toxin extrusion protein 1 1
- ...
Publications 15 ▿
- Neuropharmacology 34: 533-40 (1995) 7
- ACS Med Chem Lett 9: 198-203 (2018) 5
- J Pharmacol Exp Ther 303: 959-68 (2002) 4
- Drug Metab Dispos 33: 495-9 (2005) 2
- Bioorg Med Chem 23: 4277-85 (2015) 1
- J Med Chem 56: 9265-74 (2013) 1
- Eur J Med Chem 159: 206-216 (2018) 1
- J Med Chem 59: 1207-16 (2016) 1
- J Med Chem 60: 1716-1733 (2017) 1
- J Med Chem 56: 781-95 (2013) 1
- J Med Chem 54: 2646-57 (2011) 1
- Bioorg Med Chem Lett 20: 4182-7 (2010) 1
- Mol Pharmacol 54: 342-52 (1998) 1
- J Med Chem 57: 5738-47 (2014) 1
- Bioorg Med Chem Lett 6: 595-600 (1996) 1
Institutions 12 ▿
- [Merz Co. GmbH & Co.] 7
- [National and Kapodistrian University of Athens] 6
- [University of Manitoba] 4
- [Universitat de Barcelona] 3
- [Tokyo University of Science] 2
- [TBA, Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster, Wuhan University, University of Athens, University of California, Institut f£r Physiologie, The University of Arizona] 1
- [TBA, Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster, Wuhan University, University of Athens, University of California, Institut f£r Physiologie, The University of Arizona] 1
- [TBA, Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster, Wuhan University, University of Athens, University of California, Institut f£r Physiologie, The University of Arizona] 1
- [TBA, Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster, Wuhan University, University of Athens, University of California, Institut f£r Physiologie, The University of Arizona] 1
- [TBA, Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster, Wuhan University, University of Athens, University of California, Institut f£r Physiologie, The University of Arizona] 1
- [TBA, Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster, Wuhan University, University of Athens, University of California, Institut f£r Physiologie, The University of Arizona] 1
- [TBA, Institut f£r Pharmazeutische und Medizinische Chemie der Westf£lischen Wilhelms-Universit£t M£nster, Wuhan University, University of Athens, University of California, Institut f£r Physiologie, The University of Arizona] 1
Affinity: 20 to 5.0E+5 nM▿
- Ki 9
- IC50 17
- Kd 6
- EC50 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1