null
SMILES NC(=O)c1cnc2[nH]ccc2c1NC1C2CC3CC1CC(O)(C3)C2
InChI Key InChIKey=DREIJXJRTLTGJC-UHFFFAOYSA-N
PDB links: 4 PDB IDs match this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50463838
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astellas Pharma Inc.
Curated by ChEMBL
Astellas Pharma Inc.
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged TYK2 catalytic domain (871 to 1187 residues) expressed in baculovirus expression system using B...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astellas Pharma Inc.
Curated by ChEMBL
Astellas Pharma Inc.
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of TYK2 JH1 domain (unknown origin) in presence of Km ATPMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astellas Pharma Inc.
Curated by ChEMBL
Astellas Pharma Inc.
Curated by ChEMBL
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human TYK2 kinase domain using biotin-IRS1-substrate as substrate incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Astellas Pharma Inc.
Curated by ChEMBL
Astellas Pharma Inc.
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human Tyk2 using Biotin-Lyn-Substrate-2 in presence of 1 mM ATP by phosphotyrosine-specific ELISAMore data for this Ligand-Target Pair