null
SMILES CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InChI Key InChIKey=PMATZTZNYRCHOR-CGLBZJNRSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 34 hits for monomerid = 50022815
Affinity DataKi: 1.5nMpH: 7.8Assay Description:The protease-free PPIase assay measures the rate of cis to trans conversion of a peptide substrate catalyzed by the enzyme cyclophilin A. Addition of...More data for this Ligand-Target Pair
Affinity DataKi: 2.64nMAssay Description:Inhibition of calcineurin phosphatase activity of CyPAMore data for this Ligand-Target Pair
Affinity DataKi: 6.70nMAssay Description:Inhibition of full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed in Escherichia coli BL21(DE3) using Su...More data for this Ligand-Target Pair
Affinity DataKi: 9.79nMAssay Description:Inhibition of human recombinant cyclophilin-associted cis-trans propyl isomerase activityMore data for this Ligand-Target Pair
Affinity DataKi: 12nMAssay Description:Inhibition of CypA PPIase activity (unknown origin) using Glt-(Ala)n-Pro-Phe-4-nitroanilides as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of cyclophilin A rotamaseMore data for this Ligand-Target Pair
Affinity DataKi: 227nMAssay Description:Inhibition of Cyclophilin 18 PPIase activityMore data for this Ligand-Target Pair
Affinity DataKi: 231nMAssay Description:Inhibition of fluorescein labeled cyclosporin binding to Cyp18 by flourescence polarization competition assayMore data for this Ligand-Target Pair
Affinity DataIC50: 62nMAssay Description:In vitro binding affinity of the compound against cyclophilin A by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 40.7nMAssay Description:Inhibition of peptidyl-prolyl isomerase activity of Cyclophilin AMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70nMAssay Description:Inhibition of PPIase activity of cyclophilin 18 by protease coupled assayMore data for this Ligand-Target Pair
Affinity DataKd: 9nMAssay Description:Binding affinity to human cyclophilin 18 assessed as reduction in calcineurin activityMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Binding affinity to human cyclophilin 18More data for this Ligand-Target Pair
Affinity DataKd: 7.60nMAssay Description:Binding affinity to human recombinant cyclophilin-A by isothermal titration calorimetry assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMAssay Description:Inhibition of PPIase activity of human recombinant cyclophilin-A using succinyl-Ala-Ala-Pro-Phe-4-nitroanilide as substrate by protease coupled assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Immunosuppressive activity was measured by inhibition of the IL-2 production in Jurkat cells.More data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:Binding affinity towards cyclophilin A by fluorescenceMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Compound was evaluated for in vitro binding affinity to cyclophilin A (CyP-A)More data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:In vitro binding affinity of the compound against cyclophilin A by rotamase assayMore data for this Ligand-Target Pair
Affinity DataKd: 36.8nMAssay Description:Binding affinity to human Cyclophilin AMore data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Competitive binding affinity to biotinylated human recombinant T cell cyclophilin A expressed in Escherichia coli by spectrophotometric analysisMore data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Binding affinity to cyclophilin A by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Binding affinity to human cyclophilin A by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataIC50: 10.3nMAssay Description:Inhibition of PPIase activity of Cyclophilin A by SpectrophotometryMore data for this Ligand-Target Pair
Affinity DataKd: 6.42E+3nMAssay Description:Binding affinity to Cyclophilin AMore data for this Ligand-Target Pair
Affinity DataIC50: 8.33nMAssay Description:Binding affinity to cyclophilin A by ELISAMore data for this Ligand-Target Pair
Affinity DataKd: 10nMAssay Description:Inhibition of fluorescent cyclosporin A binding to human CypA by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Inhibition of Cy5-labeled cyclosporin A binding to full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed i...More data for this Ligand-Target Pair
Affinity DataKd: 17nMAssay Description:Inhibition of Cy5-labeled cyclosporin A binding to full length recombinant human N-terminal His8-tagged Cyclophilin A (1 to 169 residues) expressed i...More data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of Cyclophilin A peptidyl-prolyl cis-trans isomerase activity (unknown origin) using Succ-Ala-Leu-Pro-Phe-p-nitroaniline as substrate by I...More data for this Ligand-Target Pair
Affinity DataKd: 2.5nMAssay Description:Binding affinity to Cyclophilin A (unknown origin) by surface plasmon resonance analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of CypA (unknown origin) assessed as peptidyl-prolyl cis-trans isomerase activity using N-succinyl-Ala-Ala-Pro-Phe-p-nitroanilide as subst...More data for this Ligand-Target Pair
In DepthDetails