BindingDB

null

SMILES O=C\C=C\c1ccccc1

InChI Key InChIKey=KJPRLNWUNMBNBZ-QPJJXVBHSA-N

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50203065

Polyphenol oxidase 2(Agaricus bisporus (Common mushroom))
Chungnam National University

Curated by ChEMBL

BDBM50203065(3-phenylacrylaldehyde | 3-phenylprop-2-enal | CHEM...)copy SMILEScopy InChI

IC50: 5.20E+5nMAssay Description:Inhibition of mushroom tyrosinase after 10 mins by spectrophotometryMore data for this Ligand-Target Pair

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Details Article
BindingDB Entry DOI: 10.7270/Q2QF8T0KPubMed

Targets 7 ▿
- Transient receptor potential cation channel subfamily A member 1 6
- Cell division protein FtsZ 2
- Transient receptor potential cation channel subfamily M member 8 2
- Polyunsaturated fatty acid 5-lipoxygenase 1
- Prostaglandin G/H synthase 2 1
- Polyphenol oxidase 2 1
- Xanthine dehydrogenase/oxidase 1
Publications 10 ▿
- Eur J Med Chem 170: 141-156 (2019) 3
- Eur J Med Chem 95: 1-15 (2015) 2
- J Nat Prod 77: 285-97 (2014) 2
- Bioorg Med Chem 27: 3745-3759 (2019) 1
- Bioorg Med Chem Lett 20: 276-9 (2010) 1
- Nature 445: 541-545 (2007) 1
- J Med Chem 53: 5085-107 (2010) 1
- J Nat Prod 68: 985-91 (2005) 1
- J Nat Prod 72: 1205-8 (2009) 1
- Bioorg Med Chem Lett 22: 4625-8 (2012) 1
Institutions 10 ▿
- [University of Hull] 3
- [Shandong University, University of Shizuoka] 2
- [Shandong University, University of Shizuoka] 2
- [School of Advanced Sciences, Uppsala University, The Scripps Research Institute, Ferrara University, Renovis, Inc., Chungnam National University, National Institute of Medicinal Materials] 1
- [School of Advanced Sciences, Uppsala University, The Scripps Research Institute, Ferrara University, Renovis, Inc., Chungnam National University, National Institute of Medicinal Materials] 1
- [School of Advanced Sciences, Uppsala University, The Scripps Research Institute, Ferrara University, Renovis, Inc., Chungnam National University, National Institute of Medicinal Materials] 1
- [School of Advanced Sciences, Uppsala University, The Scripps Research Institute, Ferrara University, Renovis, Inc., Chungnam National University, National Institute of Medicinal Materials] 1
- [School of Advanced Sciences, Uppsala University, The Scripps Research Institute, Ferrara University, Renovis, Inc., Chungnam National University, National Institute of Medicinal Materials] 1
- [School of Advanced Sciences, Uppsala University, The Scripps Research Institute, Ferrara University, Renovis, Inc., Chungnam National University, National Institute of Medicinal Materials] 1
- [School of Advanced Sciences, Uppsala University, The Scripps Research Institute, Ferrara University, Renovis, Inc., Chungnam National University, National Institute of Medicinal Materials] 1
Affinity: 5.8E+3 to 5.2E+5 nM▿
- IC50 8
- EC50 6
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1