BindingDB

null

SMILES OC(=O)Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1

InChI Key InChIKey=UOWZUVNAGUAEQC-UHFFFAOYSA-N

PDB links: 13 PDB IDs match this monomer. 2 PDB IDs contain this monomer as substructures. 2 PDB IDs contain inhibitors having a similarity of 90% to this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 18862

Proliferating cell nuclear antigen(Homo sapiens (Human))
St. Jude Children's Research Hospital

Curated by ChEMBL

BDBM18862(2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]ac...)copy SMILEScopy InChI

IC50: 2.50E+4nMAssay Description:Inhibition of human recombinant PCNA interaction with PIP box protein N-5-carboxyfluorescein-SAVLQKKITDYFHPKK after 30 mins by fluorescence polarizat...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Purchase CHEMBL DrugBank MCE
MMDB PC cid PC sid PDB Patents

Details Article
BindingDB Entry DOI: 10.7270/Q2JQ12CZPubMed

Targets 9 ▿
- Thyroid hormone receptor beta 5
- Sodium/bile acid cotransporter 3
- Peroxisome proliferator-activated receptor gamma 2
- Thyroid hormone receptor alpha 2
- Retinoic acid receptor RXR-alpha 2
- Solute carrier organic anion transporter family member 1C1 1
- Putative hydrolase 1
- Proliferating cell nuclear antigen 1
- Androgen receptor 1
Publications 10 ▿
- J Med Chem 63: 6727-6740 (2020) 4
- J Med Chem 46: 1580-8 (2003) 2
- J Med Chem 38: 695-707 (1995) 2
- Bioorg Med Chem 15: 4609-17 (2007) 2
- Bioorg Med Chem 21: 1972-7 (2013) 1
- Endocrinology 145: 4384-91 (2004) 1
- Bioorg Med Chem 15: 5251-61 (2007) 1
- Bioorg Med Chem Lett 29: (2019) 1
- J Med Chem 54: 8563-73 (2011) 1
- Bioorg Med Chem Lett 19: 4280-3 (2009) 1
Institutions 10 ▿
- [Goethe-University Frankfurt] 4
- [Karo Bio AB, Ciba Pharmaceuticals, Universidade de S£o Paulo] 2
- [Karo Bio AB, Ciba Pharmaceuticals, Universidade de S£o Paulo] 2
- [Karo Bio AB, Ciba Pharmaceuticals, Universidade de S£o Paulo] 2
- [St. Jude Children's Research Hospital, The University of Tokyo, University of Insubria, University of British Columbia, AstraZeneca, Southwest Jiaotong University] 1
- [St. Jude Children's Research Hospital, The University of Tokyo, University of Insubria, University of British Columbia, AstraZeneca, Southwest Jiaotong University] 1
- [St. Jude Children's Research Hospital, The University of Tokyo, University of Insubria, University of British Columbia, AstraZeneca, Southwest Jiaotong University] 1
- [St. Jude Children's Research Hospital, The University of Tokyo, University of Insubria, University of British Columbia, AstraZeneca, Southwest Jiaotong University] 1
- [St. Jude Children's Research Hospital, The University of Tokyo, University of Insubria, University of British Columbia, AstraZeneca, Southwest Jiaotong University] 1
- [St. Jude Children's Research Hospital, The University of Tokyo, University of Insubria, University of British Columbia, AstraZeneca, Southwest Jiaotong University] 1
Affinity: 0.041 to 3.5E+4 nM▿
- Ki 1
- IC50 13
- Kd 2
- EC50 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 1
Catalog Cmpds: 1