null

SMILES Cc1ccc(cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=ZNVCVMODGVQVMO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 202666   

TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202666(US10245267, Example 11 | US10709712, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2280BP3US Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202666(US10245267, Example 11 | US10709712, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.542nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB76WPUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202666(US10245267, Example 11 | US10709712, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB76WPUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202666(US10245267, Example 11 | US10709712, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.542nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2280BP3US Patent