null

SMILES Cc1ccc(cc1-c1cc(nc(n1)N1CCOCC1)N1CCOCC1)C(=O)Nc1cccc(c1)C(F)(F)F

InChI Key InChIKey=ZNVCVMODGVQVMO-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 202666   

TargetRAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202666(US10245267, Example 11 | US10709712, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.540nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202666(US10245267, Example 11 | US10709712, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetRAF proto-oncogene serine/threonine-protein kinase [Y340E,Y341E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM202666(US10245267, Example 11 | US10709712, Example 11 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.542nMpH: 7.5 T: 2°CAssay Description:Final assay conditions were 4 pM cRaf, 3 uM ATP, 10 nM biotin tagged MEK1 kinase dead protein substrate. Reactions were performed in Greiner384 well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2VT1QXTUS Patent