null

SMILES CC(C)(C)c1cc(NC(=O)Nc2ccc(cc2)-c2cn3c(n2)sc2cc(OCCN4CCOCC4)ccc32)no1

InChI Key InChIKey=CVWXJKQAOSCOAB-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 75 hits for monomerid = 50300690   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:FLT3 is a receptor tyrosine kinase involved in survival and proliferation of leukemic cells. Constitutively activating FLT3 mutations has been found ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2PK0F02US Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of FLT3 kinase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4X94PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  1.60nMAssay Description:Binding affinity to FLT3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95V2PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of FLT3 autophosphorylation in human RS4-11 cells after 2 hrs by electrochemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95V2PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  1.60nMAssay Description:Binding affinity to FLT3 catalytic domain by KinomeScan kinase binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95V2PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  7.10nMAssay Description:Binding constant for FLT3(D835Y) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8S70PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  8.80nMAssay Description:Binding constant for FLT3(ITD) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8S70PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  2.20nMAssay Description:Binding constant for FLT3(K663Q) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8S70PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  1.30nMAssay Description:Binding constant for FLT3 kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8S70PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  3.70nMAssay Description:Binding constant for FLT3(D835H) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8S70PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  5.10nMAssay Description:Binding constant for FLT3(R834Q) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8S70PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 137nMAssay Description:Inhibition of human FLT D835Y mutant using 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X35038PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of human FLT3 using 10 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X35038PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of FLT3 (unknown origin) using FAM-EPLYWSFPA as substrate preincubated for 60 mins followed by substrate addition by microfluidics assay i...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039VCPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of wild type GST-tagged FLT3 kinase domain (Y567 to S993) (unknown origin) expressed in baculovirus infected insect Sf9 cells using Her2 p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7J12PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Competitive inhibition of FLT3 ITD mutant (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HD7XJDPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 93nMAssay Description:Competitive inhibition of FLT3 D835Y mutant (unknown origin) in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HD7XJDPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  1.60nMAssay Description:Binding affinity to FLT3 catalytic domain expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2319VZ6PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of FLT3 autophosphorylation in human AML cells isolated from relapsed acute myeloid leukemia patient by Western blottingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN95V2PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  1.60nMAssay Description:Binding affinity to FLT3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29C6XPMPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  4.10nMAssay Description:Binding constant for FLT3(N841I) kinase domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25D8S70PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human FLT3 expressed in insect Sf21 cells preincubated for 15 mins followed by poly(Glu:Tyr) substrate addition for 30 mins...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BG2QX3PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of wild type GST tagged FLT3 kinase (567 to 993) (unknown origin) transfected in insect sf9 cells after 4 hrs by wallac counting analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22N53NFPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of wild type FLT3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5WGVPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human wild-type FLT3 (564 to end residues) expressed in baculovirus infected sf21 cells using Abltide...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SF2ZFDPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of human HL60 cells-derived His-tagged FLT3 (564 to 993 residues) expressed in baculovirus infected sf9 cells using poly (4:1 Glu, Tyr) as...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2474D9SPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 15.9nMAssay Description:In the experiments of in vitro enzymatic activity, the IC50 values of Compound 33, Compound 30, Compound 14, Compound 20, Compound 22, Compound 23, C...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25141JMUS Patent
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 136nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) D835Y mutant expressed in Sf9 insect cells using poly (Ala,Glu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3PR1PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant human FLT3 (R571 to S993 residues) ITD mutant expressed in Sf9 insect cells using poly (Ala,Glu,L...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3PR1PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of N-terminal GST/His6-fused recombinant wild type human FLT3 (R571 to S993 residues) expressed in Sf9 insect cells using poly (Ala,Glu,Ly...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3PR1PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of wild-type human partial length FLT3 (V592 to Y969 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27947ZVPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human partial length FLT3 ITD mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27947ZVPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of FLT3 ITD mutant (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IM...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27947ZVPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 1.33E+3nMAssay Description:Inhibition of FLT3 D835Y (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP-FP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27947ZVPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of wildtype FLT3 (unknown origin) using TAMRA-Src-tide as substrate measured after 1 hr in presence of ATP at its Km concentration by IMAP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27947ZVPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 7.40nMAssay Description:Inhibition of recombinant human FLT3 (564 to end residues) using EAIYAAPFAKKK as substrate measured after 40 mins in presence of [gamma-33P]-ATP by s...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QJ7MPQPubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 0.510nMAssay Description:Inhibition of human FLT3 using EAIYAAPFAKKK substrate and [gamma-33P]-ATP by radiometric biochemical kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H41VR7PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  8.80nMAssay Description:Binding affinity to human FLT3 ITD mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26113R9PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  1.30nMAssay Description:Binding affinity to non-auto-inhibited form of wild type human N-terminal GST-tagged FLT3 expressed in baculovirus expressionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26113R9PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  3.70nMAssay Description:Binding affinity to human FLT3 D835H mutant expressed in baculovirus expression systemMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26113R9PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  8.80nMAssay Description:Binding affinity to FLT3 ITD mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38X35PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  3.70nMAssay Description:Binding affinity to FLT3 D835H mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38X35PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  7.10nMAssay Description:Binding affinity to FLT3 D835Y mutant (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38X35PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  1.30nMAssay Description:Binding affinity to wild type FLT3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38X35PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of FLT3 (unknown origin) (592 to 969 residues)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J38X35PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human N-terminal GST/His6-tagged FLT3 ITD mutant (571 to 993 residues) expressed in Sf9 cells using Tyr2 peptide as substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5RR3PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  1.30nMAssay Description:Binding affinity to recombinant human FLT3 (592 to 969 residues) expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5RR3PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  3.60nMAssay Description:Binding affinity to recombinant human FLT3 ITD mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5RR3PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  420nMAssay Description:Binding affinity to recombinant human FLT3 ITD/D835V double mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5RR3PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Shanghai De Novo Pharmatech Co Ltd.

US Patent
LigandPNGBDBM50300690(1-(5-Tert-Butyl-1,2-Oxazol-3-Yl)-3-(4-{7-[2-(Morph...)copy SMILEScopy InChI
Affinity DataKd:  55nMAssay Description:Binding affinity to recombinant human FLT3 ITD/F691L double mutant expressed in bacterial expression system by Kinomescan methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5RR3PubMed