BindingDB

null

SMILES CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@@H]1[C@H](O)Cc2ccccc12

InChI Key InChIKey=CBVCZFGXHXORBI-PXQQMZJSSA-N

PDB links: 15 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50067593

Replicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)TBA

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)copy SMILEScopy InChI

IC50: 3.15E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Purchase DrugBank MCE
KEGG PC cid PC sid PDB Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2J1069FPubMed

Replicase polyprotein 1ab(2019-nCoV)TBA

BDBM50067593(CHEBI:44032 | Crixivan | Indinavir | L-735524 | MK...)copy SMILEScopy InChI

IC50: 1.36E+4nMAssay Description:This is a review article. Please point to the original journal.More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank GoogleScholar

Purchase DrugBank MCE
KEGG PC cid PC sid PDB Similars

Details Article
BindingDB Entry DOI: 10.7270/Q2J1069FPubMed

Targets 11 ▿
- Protease 13
- HIV-1 protease 6
- Bile salt export pump 3
- Replicase polyprotein 1ab 2
- Nuclear receptor subfamily 1 group I member 2 2
- ATP-binding cassette sub-family C member 3 1
- Gag-Pol polyprotein [489-587,G537V,H558K,V571A] 1
- ATP-binding cassette sub-family C member 4 1
- Gag-Pol polyprotein [489-587] 1
- Solute carrier family 22 member 1 1
- ATP-binding cassette sub-family C member 2 1
Publications 18 ▿
- J Med Chem 51: 4839-43 (2008) 6
- Toxicol Sci 136: 216-41 (2013) 4
- Bioorg Med Chem 20: 4838-47 (2012) 3
- Drug Metab Dispos 39: 151-9 (2010) 2
- US Patent US10806794 (2020) 1
- Bioorg Med Chem Lett 17: 5432-6 (2007) 1
- J Med Chem 61: 3779-3798 (2018) 1
- Eur J Med Chem 45: 4096-103 (2010) 1
- Bioorg Med Chem 16: 1299-308 (2008) 1
- Drug Metab Dispos 28: 329-34 (2000) 1
- J Med Chem 51: 1053-7 (2008) 1
- J Med Chem 53: 607-15 (2010) 1
- J Med Chem 57: 6266-72 (2014) 1
- Toxicol Sci 118: 485-500 (2010) 1
- Bioorg Med Chem Lett 24: 2465-8 (2014) 1
- Bioorg Med Chem Lett 18: 5406-10 (2008) 1
- Hepatology 60: 1015-22 (2014) 1
- Bioorg Med Chem Lett 25: 1880-3 (2015) 1
Institutions 17 ▿
- [Academy of Sciences of the Czech Republic] 6
- [Amgen Inc] 4
- [Universidad de Santiago de Compostela] 3
- [Uppsala University, National Institutes of Health Chemical Genomics Center] 2
- [Uppsala University, National Institutes of Health Chemical Genomics Center] 2
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
- [CSIR-National Chemical Laboratory, Merck Research Laboratories, Pfizer Inc., Beijing Institute of Biotechnology, Dainippon Sumitomo Pharma Co., Ltd., Philipps-Universit£t Marburg, University of Minnesota, University of California, Chinese Academy of Medical Sciences and Peking Union Medical College, Shandong University, Nektar Therapeutics, Amgen Inc.] 1
Affinity: 0.12 to 1.3E+5 nM▿
- Ki 12
- IC50 15
- Kd 3
- EC50 2
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1