null

SMILES Cc1ncc(NC(=O)c2cccc(c2)C(F)(F)F)cc1-c1cc(N2CCOCC2)c(OC2CCOCC2)nn1

InChI Key InChIKey=FLNNBUNPCWDUJJ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 84365   

TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM84365(US10245267, Example 636 | US10709712, Example 636 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMpH: 7.5 T: 2°CAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2x final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MC8X6WUS Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM84365(US10245267, Example 636 | US10709712, Example 636 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Raf and biotinylated Mek, kinase dead, were combined at 2× final concentrations in assay buffer (50 mM Tris, pH 7.5, 15 mM MgCl2, 0.01% BSA and 1 mM ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2RB76WPUS Patent
TargetSerine/threonine-protein kinase B-raf [V600E](Homo sapiens (Human))
NOVARTIS AG

US Patent
LigandPNGBDBM84365(US10245267, Example 636 | US10709712, Example 636 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:C-Raf TR refers to a truncated C-Raf protein, a Δ1-324 deletion mutant.C-Raf FL refers to the full-length C-Raf protein.Full length MEK1 with an...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2280BP3US Patent