null

SMILES CN(C)Cc1ccc(\C=C\c2n[nH]c3cc(ccc23)[C@@H]2C[C@@]22C(=O)Nc3ccccc23)cc1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50044657   

TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
EntreMed Inc.

Curated by ChEMBL
LigandPNGBDBM50044657(CHEMBL3353347 | US10358436, Example A24 | US990780...)copy SMILES
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human N-terminal GST-tagged PLK4 (1 to 391 residues) expressed in Escherichia coli incubated for 30 mins by ELISA methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2125V9WPubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
EntreMed Inc.

Curated by ChEMBL
LigandPNGBDBM50044657(CHEMBL3353347 | US10358436, Example A24 | US990780...)copy SMILES
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PLK4 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0475VPubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
EntreMed Inc.

Curated by ChEMBL
LigandPNGBDBM50044657(CHEMBL3353347 | US10358436, Example A24 | US990780...)copy SMILES
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PLK4 (unknown origin) by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M0475VPubMed
TargetSerine/threonine-protein kinase PLK4(Homo sapiens (Human))
EntreMed Inc.

Curated by ChEMBL
LigandPNGBDBM50044657(CHEMBL3353347 | US10358436, Example A24 | US990780...)copy SMILES
Affinity DataIC50: 100nMAssay Description:PLK4 activity was measured using an indirect ELISA detection system. Dephosphorylated GST-PLK4 (4 nM) was incubated in the presence of 15 μM ATP...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KD216WUS Patent