null

SMILES Nc1cc(c(cn1)-c1nc(nc(n1)N1CCOCC1)N1CCOCC1)C(F)(F)F

InChI Key InChIKey=ADGGYDAFIHSYFI-UHFFFAOYSA-N

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50240975   

TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)copy SMILEScopy InChI
Affinity DataKi:  62nMAssay Description:Displacement of Alexafluor labelled kinase tracer314 from recombinant human C-terminal GST-tagged mTOR (1360 to 2549 amino acids) expressed in insect...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29G5R5GPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)copy SMILEScopy InChI
Affinity DataKi:  62nMAssay Description:Inhibition of human C-terminal GST-tagged mTOR (1360 to 2549 residues) expressed in baculovirus expression system using after 1 hr AlexaFluor647-labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1GKPPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)copy SMILEScopy InChI
Affinity DataKi:  62nMAssay Description:Inhibition of alexa fluor 647-labeled kinase tracer 314 binding to recombinant human N-terminal GST-fused mTOR (1360 to 2549 residues) expressed in b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5JW1PubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)copy SMILEScopy InChI
Affinity DataKi:  62nMAssay Description:Antagonist activity was determined against beta-1 adrenergic receptor in spontaneously beating rat atriaMore data for this Ligand-Target Pair
In DepthDetails
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)copy SMILEScopy InChI
Affinity DataIC50: 89nMAssay Description:Displacement of [3H]baclofen from gamma-aminobutyric-acid B receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1GKPPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)copy SMILEScopy InChI
Affinity DataIC50: 205nMAssay Description:Inhibition of mTOR in human A2058 cells assessed as reduction in phosphorylation of S6 at ser235/236 residues after 1 hr by in-cell Western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1GKPPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)copy SMILEScopy InChI
Affinity DataIC50: 89nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50240975(CHEMBL4084907)copy SMILEScopy InChI
Affinity DataKd:  12nMAssay Description:Binding affinity to human mTOR (L1382 to W2549 residues) expressed in mammalian expression system at 10 uMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1GKPPubMed