BindingDB

null

SMILES CC(N)Cc1ccccc1

InChI Key InChIKey=KWTSXDURSIMDCE-UHFFFAOYSA-N

PDB links: 4 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50005246

Sigma non-opioid intracellular receptor 1(RAT)
TBA

Curated by PDSP K_i Database

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)copy SMILEScopy InChI

Ki: >1.00E+4nMMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

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Details Article
BindingDB Entry DOI: 10.7270/Q2JM284NPubMed

Sigma non-opioid intracellular receptor 1(RAT)
TBA

Curated by PDSP K_i Database

BDBM50005246(1-Phenylpropan-2-amin | 1-phenyl-2-aminopropane | ...)copy SMILEScopy InChI

Ki: >5.00E+4nMAssay Description:Binding affinity towards sigma opioid receptor was determined in rat cerebral homogenate using [3H]haloperidol as radioligandMore data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
GoogleScholar

Purchase DrugBank KEGG PC cid PC sid PDB Patents Similars

Details
BindingDB Entry DOI: 10.7270/Q28C9WV8PubMed

Targets 24 ▿
- Sodium-dependent dopamine transporter 9
- Sodium-dependent serotonin transporter 5
- Alpha-1A adrenergic receptor 4
- Norepinephrine transporter 4
- 5-hydroxytryptamine receptor 2C 3
- 5-hydroxytryptamine receptor 2A 3
- Serotonin 2 (5-HT2) receptor 3
- Phenylethanolamine N-methyltransferase 3
- 5-hydroxytryptamine receptor 1A/1B/1D/1F 2
- Alpha-2C adrenergic receptor 2
- Sigma non-opioid intracellular receptor 1 2
- Sodium-dependent noradrenaline transporter 2
- Beta-2 adrenergic receptor 2
- Solute carrier family 22 member 3 1
- D(3) dopamine receptor 1
- Amine oxidase [flavin-containing] A 1
- D(2) dopamine receptor 1
- 5-hydroxytryptamine receptor 2B 1
- 5-hydroxytryptamine receptor 1A 1
- D(1A) dopamine receptor 1
- 5-hydroxytryptamine receptor 3A 1
- Transporter 1
- Cytochrome P450 2A6 1
- Cytochrome P450 2A5 1
- ...
Publications 25 ▿
- NIDA Res Monogr 178: 440-66 (1998) 7
- Eur J Pharmacol 166: 493-504 (1989) 6
- Mol Pharmacol 13: 454-73 (1977) 4
- J Pharmacol Exp Ther 301: 1097-102 (2002) 3
- Synapse 39: 32-41 (2001) 3
- Mol Pharmacol 45: 125-35 (1994) 3
- J Med Chem 19: 725-7 (1976) 2
- J Med Chem 30: 1-12 (1987) 2
- J Med Chem 48: 440-9 (2005) 2
- Mol Pharmacol 12: 568-80 (1976) 2
- J Med Chem 21: 78-82 (1978) 2
- J Med Chem 43: 3074-84 (2000) 2
- J Med Chem 29: 194-9 (1986) 2
- J Med Chem 35: 734-40 (1992) 2
- J Pharmacol Exp Ther 241: 1092-8 (1987) 2
- J Pharmacol Exp Ther 307: 138-45 (2003) 2
- Bioorg Med Chem 17: 2452-60 (2009) 1
- J Med Chem 24: 1414-21 (1982) 1
- J Med Chem 25: 1204-8 (1983) 1
- J Med Chem 25: 1248-50 (1983) 1
- J Med Chem 25: 1198-204 (1983) 1
- J Med Chem 60: 2605-2628 (2017) 1
- Proc Natl Acad Sci U S A 81: 4983-7 (1984) 1
- J Med Chem 34: 1094-8 (1991) 1
- J Biol Chem 273: 32776-86 (1998) 1
Institutions 12 ▿
- [TBA] 19
- [SRI International] 7
- [Novo Industri A/S, Virginia Commonwealth University] 6
- [Novo Industri A/S, Virginia Commonwealth University] 6
- [Harvard University, NIH, University of Toronto] 3
- [Harvard University, NIH, University of Toronto] 3
- [Harvard University, NIH, University of Toronto] 3
- [University of California, National Institute on Drug Abuse, University of Kuopio] 2
- [University of California, National Institute on Drug Abuse, University of Kuopio] 2
- [University of California, National Institute on Drug Abuse, University of Kuopio] 2
- [University of Chile, Medical College of Georgia] 1
- [University of Chile, Medical College of Georgia] 1
Affinity: 7.1 to 7.4E+5 nM▿
- Ki 47
- IC50 7
- Kd 1
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 1