null
SMILES Cc1ncc(F)cc1NC(=O)C[C@@H](C1CC1)C(=O)N[C@H]1c2ccccc2C(=O)N2CC3(CC3)CN2C1=O
InChI Key InChIKey=WLQXBRYTQYYCMW-REWPJTCUSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50263004
TargetSignal peptide peptidase-like 2A(Homo sapiens)
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Curated by ChEMBL
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of human SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 76 residues) NTF as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Homo sapiens)
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Curated by ChEMBL
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells using GAL4-VP16 fusedTNFalpha (1 to 76)-NTF as substrate after 24 hrs by Bright-Glo luciferase r...More data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Mus musculus)
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Curated by ChEMBL
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Curated by ChEMBL
Affinity DataIC50: 137nMAssay Description:Inhibition of mouse SPPL2a in A20 cells assessed as CD74/p8 accumulation by flow cytometryMore data for this Ligand-Target Pair
TargetSignal peptide peptidase-like 2A(Mus musculus)
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Curated by ChEMBL
The Genomics Institute of the Novartis Research Foundation , 10675 John Jay Hopkins Drive, San Diego, California 92121, United States.
Curated by ChEMBL
Affinity DataIC50: 180nMAssay Description:Inhibition of mouse SPPL2a expressed in human U2OS cells using EGFP-labeled TNFalpha (1 to 77 residues) NLS as substrate after 24 hrs by Hoechst stai...More data for this Ligand-Target Pair