BindingDB

null

SMILES CN(C)CCCN1c2ccccc2Sc2ccccc12

InChI Key InChIKey=ZGUGWUXLJSTTMA-UHFFFAOYSA-N

PDB links: 2 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 67545

Sodium channel protein type 1/2/3 subunit alpha(Homo sapiens (Human))
TBA

Curated by ChEMBL

BDBM67545(N,N-dimethyl-3-(10-phenothiazinyl)-1-propanamine;h...)copy SMILEScopy InChI

IC50: 5.40E+3nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
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Details
BindingDB Entry DOI: 10.7270/Q2Z321T8PubMed

Targets 20 ▿
- Histamine H1 receptor 5
- D(2) dopamine receptor 5
- Alpha-1A adrenergic receptor 2
- D(1A) dopamine receptor 2
- Muscarinic acetylcholine receptor M2 2
- Alpha-2A adrenergic receptor 2
- Pleiotropic ABC efflux transporter of multiple drugs 1
- Solute carrier family 22 member 1 1
- Glutathione S-transferase P/Mucosa-associated lymphoid tissue lymphoma translocation protein 1 1
- Beta-2 adrenergic receptor 1
- Lysine-specific histone demethylase 1A 1
- D(3) dopamine receptor 1
- 5-hydroxytryptamine receptor 2C 1
- D(1A)/D(2) dopamine receptor 1
- NADPH oxidase 1 1
- 5-hydroxytryptamine receptor 1A/1B/1D/2C 1
- Major prion protein 1
- Sodium channel protein type 1/2/3 subunit alpha 1
- D(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor 1
- Trypanothione reductase 1
Publications 16 ▿
- Ann N Y Acad Sci 537: 435-42 (1988) 7
- Eur J Pharmacol 103: 197-204 (1984) 5
- J Neuropsychiatry Clin Neurosci 8: 223-6 (1996) 2
- J Med Chem 23: 938-41 (1980) 2
- J Med Chem 55: 7054-60 (2012) 2
- J Pharmacol Exp Ther 315: 1278-87 (2005) 2
- Mol Pharmacol 12: 800-12 (1976) 2
- J Med Chem 41: 148-56 (1998) 1
- US Patent US9504692 (2016) 1
- Antimicrob Agents Chemother 53: 1516-27 (2009) 1
- Mol Pharmacol 12: 568-80 (1976) 1
- J Med Chem 28: 381-8 (1985) 1
- PubChem Bioassay (2010) 1
- Proc Natl Acad Sci U S A 75: 6290-4 (1978) 1
- J Med Chem 51: 5932-42 (2008) 1
- J Med Chem 46: 3563-4 (2003) 1
Institutions 10 ▿
- [Mayo Clinic and Foundation] 12
- [TBA] 9
- [ACADIA Pharmaceuticals, University of Oxford] 2
- [ACADIA Pharmaceuticals, University of Oxford] 2
- [Wroclaw Medical University, University of Manchester, Uppsala University, HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH), The Scripps Research Institute Molecular Screening Center, Institut f£r Molekularbiologie und Biophysik] 1
- [Wroclaw Medical University, University of Manchester, Uppsala University, HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH), The Scripps Research Institute Molecular Screening Center, Institut f£r Molekularbiologie und Biophysik] 1
- [Wroclaw Medical University, University of Manchester, Uppsala University, HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH), The Scripps Research Institute Molecular Screening Center, Institut f£r Molekularbiologie und Biophysik] 1
- [Wroclaw Medical University, University of Manchester, Uppsala University, HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH), The Scripps Research Institute Molecular Screening Center, Institut f£r Molekularbiologie und Biophysik] 1
- [Wroclaw Medical University, University of Manchester, Uppsala University, HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH), The Scripps Research Institute Molecular Screening Center, Institut f£r Molekularbiologie und Biophysik] 1
- [Wroclaw Medical University, University of Manchester, Uppsala University, HELMHOLTZ ZENTRUM MUNCHEN, DEUTSCHES FORSCHUNGSZENTRUM FUR GESUNDHEIT UND UMWELT (GMBH), The Scripps Research Institute Molecular Screening Center, Institut f£r Molekularbiologie und Biophysik] 1
Affinity: 2 to 5.9E+4 nM▿
- Ki 21
- IC50 10
- EC50 1
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 1