null

SMILES CC(C)(N1CCC(COc2cc(F)c(cc2C2CC2)C(=O)NS(C)(=O)=O)CC1)c1cc(Cl)cc(Cl)c1

InChI Key InChIKey=KWAURGCHFYCYPQ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 71064   

TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent
LigandPNGBDBM71064(US9546164, 209 | US9694002, 209)copy SMILEScopy InChI
Affinity DataIC50: 18.2nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4ZS4US Patent
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent
LigandPNGBDBM71064(US9546164, 209 | US9694002, 209)copy SMILEScopy InChI
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells incubated for 1 hr in presence of veratridine and anthropleurin-C by sodium influx assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7NKSPubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
GENENTECH, INC.; XENON PHARMACEUTICALS INC.

US Patent
LigandPNGBDBM71064(US9546164, 209 | US9694002, 209)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMpH: 7.4 T: 2°CAssay Description:Radioligand Binding Studies: Saturation experiments. A representative compound of formula (I) having a methyl group was tritiated. Three tritiums wer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JD4ZS4US Patent