null

SMILES O[C@@H]1CCN(C1)c1ncc(cc1-c1cncnc1)C(=O)Nc1ccc(OC(F)(F)Cl)cc1

InChI Key InChIKey=SXTRKVXLELDRIE-MRXNPFEDSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 213578   

TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM213578(US9278981, 170)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Test compounds were resuspended in DMSO at a concentration of 10 mM. A serial three-fold dilution of each compound with DMSO was performed in 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1HRDUS Patent
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM213578(US9278981, 170)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of ABL1 (64 to 515 residues)(unknown origin) expressed in Escherichia coli using FITC-Ahx-EAIYAAPFAKKK-NH2 peptide as substrate after 60 m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FX7D3XPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Novartis AG

US Patent
LigandPNGBDBM213578(US9278981, 170)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Test compounds were resuspended in DMSO at a concentration of 10 mM. A serial three-fold dilution of each compound with DMSO was performed in 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2DV1HRDUS Patent