null

SMILES COC\C=C\C(=O)N1CCC[C@H]1c1nc(-c2ccc(cc2)C(=O)Nc2nc3CCCCc3s2)c2c(N)nccn12

InChI Key InChIKey=QLBPMCVTZXOPII-OWLMGLOSSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 340102   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM340102((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...)copy SMILEScopy InChI
Affinity DataEC50:  505nMAssay Description:Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GX4DPQUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM340102((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...)copy SMILEScopy InChI
Affinity DataEC50:  55nMAssay Description:Btk enzyme (His-Btk (Millipore catalog #14-552), is diluted to 0.4 U/mL in KR buffer (10 mM Tris-HCl, 10 mM MgCl2, 0.01% Tween-20, 0.05% NaN3, 1 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20R9RQ4US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck Sharp & Dohme B.V.

US Patent
LigandPNGBDBM340102((S,E)-4-(8-amino-3-(1-(4- methoxybut-2-enoyl)pyrro...)copy SMILEScopy InChI
Affinity DataEC50:  55nMAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below.Btk enzyme (H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27947T2US Patent